| Effect of modest alcohol consumption over 1-2 weeks on the coronary microcirculation of normal subjects. | |
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MedLine Citation:
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PMID: 20378684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: It has been reported that imbibing red wine increases coronary blood flow reserve acutely. In the absence of changes in coronary driving pressure, any increases in coronary blood flow reserve should occur through a decrease in capillary resistance, which in turn is determined by capillary dimensions and whole-blood viscosity. Since alcohol intake is unlikely to acutely change capillary dimensions, we hypothesized that it must increase coronary blood flow reserve by reducing whole-blood viscosity. METHODS AND RESULTS: Forty-five normal subjects were randomly assigned to water (n = 12), vodka (n = 11), white wine (n = 11), and red wine (n = 11). Myocardial blood flow reserve was measured at baseline and after up to 2 weeks of beverage consumption using myocardial contrast echocardiography. In addition, whole-blood viscosity and its principal determinants (haematocrit; erythrocyte deformability, mobility, and charge; plasma fibrinogen; and total serum protein, glucose, and lipids) were also measured. Systolic and diastolic blood pressure and heart rate did not change between the two examinations either at rest or following dipyridamole infusion. Neither did myocardial blood flow reserve nor whole-blood viscosity or any of its determinants. Only high-density lipoprotein-2 increased for all alcohol consumers (12.4 +/- 5.3 vs. 10.9 +/- 4.7, P = 0.007). CONCLUSION: It is concluded that modest alcohol consumption for up to 2 weeks does not increase myocardial blood flow reserve. It also does not alter whole-blood viscosity or any of its principal determinants. Therefore, the beneficial cardiovascular effects of modest alcohol consumption over 1-2 weeks cannot be attributed either to its effect on the coronary microcirculation or haemorheology. |
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Authors:
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Sanjiv Kaul; Todd Belcik; Saul Kalvaitis; Ananda R Jayaweera; Si-Wan Choi; Kevin Wei |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-04-08 |
Journal Detail:
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Title: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology Volume: 11 ISSN: 1532-2114 ISO Abbreviation: Eur J Echocardiogr Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2011-06-02 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 100890618 Medline TA: Eur J Echocardiogr Country: England |
Other Details:
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Languages: eng Pagination: 683-9 Citation Subset: IM |
Affiliation:
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Cardiovascular Medicine Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. kauls@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking* Coronary Circulation / drug effects Diastole / drug effects Dipyridamole / pharmacology Echocardiography Erythrocytes / drug effects Ethanol / pharmacology* Female Fractional Flow Reserve, Myocardial / drug effects* Hemodynamics / drug effects Humans Logistic Models Male Microcirculation / drug effects* Multivariate Analysis Myocardium* Phosphodiesterase Inhibitors / pharmacology Systole / drug effects Vasodilator Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB-002069/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents; 58-32-2/Dipyridamole; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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