Document Detail

Effect of moderate exercise on the severity of clinical signs associated with influenza virus infection in horses.
MedLine Citation:
PMID:  9844967     Owner:  NLM     Status:  MEDLINE    
The purpose of this experiment was to determine if exercising horses, infected with influenza virus, exacerbates the severity of clinical disease. Eight horses were trained on a treadmill for 42 days and then challenged with aerosolised influenza A/equine/Kentucky/91 (H3N8). Following challenge, 4 horses (exercise group) continued training for 28 days, while the other 4 horses (nonexercise group) were confined to their stalls. All horses developed clinical signs within 36 h of challenge (fever, coughing, and mucopurulent nasal discharge) and clinical scores were greater in the exercise group. Horses developed fever from Days 1-11 post challenge (PC) and were tachypnoeic and tachycardic from Days 1-14 PC. All horses lost weight within 4 days PC, but the exercise group lost an average of 20 kg more than the nonexercise group. All horses developed pneumonia, and ultrasonography revealed pulmonary consolidation and oedema by Day 7 PC that was resolving by Day 14 PC. Endoscopy and transtracheal aspirates showed airway inflammation for up to 21 days PC. While the exercise group exhibited more severe signs of clinical disease, resolution occurred for both groups on approximately Day 14 PC, and no adverse effects were noted at the end of the study. However, the potential long term effects of exercising horses acutely infected with influenza virus are unknown. Until further research is conducted in this area, it appears prudent not to exercise affected horses.
D K Gross; K W Hinchcliff; P S French; S A Goclan; K K Lahmers; M Lauderdale; J A Ellis; D M Haines; R D Slemons; P S Morley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal     Volume:  30     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  489-97     Citation Subset:  IM    
Department of Veterinary Preventive Medicine, The Ohio State University, Columbus 43210-1092, USA.
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MeSH Terms
Analysis of Variance
Exercise Test / veterinary
Fever / veterinary
Fibrinogen / analysis
Heart Rate
Horse Diseases / physiopathology*
Hypersensitivity, Delayed
Influenza A virus*
Leukocyte Count / veterinary
Lung / ultrasonography
Orthomyxoviridae Infections / physiopathology,  veterinary*
Physical Conditioning, Animal / adverse effects*
Random Allocation
Respiratory Sounds
Severity of Illness Index
Virus Shedding
Weight Loss
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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