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Effect of moderate Cu supplementation on serum metabolites, enzymes and redox state in feedlot calves.
MedLine Citation:
PMID:  21724218     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this investigation was to evaluate whether, in the nutritional management of commercial feedlots, copper (Cu) supplementation is justified to maintain the physiological requirements. This study compared beef calves fed concentrates with an average Cu basal content of 5 and 8mg/kg in growing and finishing periods (10 animals) or supplemented with 15mg/kg for each phase (20 animals) as regards production indices, metabolic parameters [glucose, nonesterified fatty acids (NEFA), cholesterol, serum urea nitrogen (SUN), creatinine, total serum protein (TSP), albumin, aspartate transaminase (AST) and γ-glutamyl transferase (GGT)] and markers of oxidative stress (reactive oxygen species (ROS) and serum antioxidant capacity (SAC)). Data were recorded at ages 12, 24 and 36weeks. In general, Cu supplementation was neither detrimental nor beneficial for animal health and performance, and the levels of the measured metabolites and enzymes were within their normal ranges stated for feedlot with the same management during the whole study. However, in keeping with reported higher hepatic Cu levels at slaughter, animals on supplemented feed had higher GGT activities at the end of the finishing stage, although the difference was not statistically significant. On the other hand, lower SAC levels at the end of the growing period in the supplemented group suggest the possibility of a positive effect of Cu supplementation on redox state. Further research is necessary to clarify the potential role of Cu in limiting the ROS production associated with fattening diets, and to evaluate the hepatobiliary consequences of supplementation, including hepatic Cu accumulation.
Authors:
C Castillo; J Hernández; M García Vaquero; M López Alonso; V Pereira; M Miranda; I Blanco; J L Benedito
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Research in veterinary science     Volume:  -     ISSN:  1532-2661     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Departamento de Patología Animal, Facultad de Veterinaria de Lugo, Universidad de Santiago de Compostela, Campus Universitario s/n, 27002 Lugo, Spain.
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