Document Detail

Effect of mode of application of papaverine on the contractile response of the internal mammary artery.
MedLine Citation:
PMID:  8205426     Owner:  NLM     Status:  MEDLINE    
A study was performed to investigate the duration of action of papaverine applied either intraluminally or in a combined intraluminal and extraluminal fashion in vitro, and how the reactivity of the internal mammary artery (IMA) to a range of vasoconstrictors is affected. Segments of IMA exposed to only intraluminal papaverine (10(-4) mol/l) for 15 min recovered their contractile response to 90 mmol/l potassium chloride to pretreatment levels within 2 h. In contrast, combined intraluminal and extraluminal administration of papaverine resulted in a significant depression of the contractile response to 90 mmol/l potassium chloride (P < 0.001), which persisted for at least 5 h. Responses to 5-hydroxytryptamine, noradrenaline, the thromboxane mimetic U46619, histamine and dopamine were not significantly different between control tissues and those that had received intraluminal papaverine. The duration of action of papaverine is affected by its route of delivery and there are no significant short-term effects on the contractile mechanisms in the arterial wall after intraluminal administration.
A H Chester; R Panda; J A Borland; S Tadjkarimi; C J Schyns; G S O'Neil; M H Yacoub
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  81     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  527-31     Citation Subset:  AIM; IM    
National Heart and Lung Institute, Harefield Hospital, Middlesex, UK.
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MeSH Terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Dopamine / pharmacology
Dose-Response Relationship, Drug
Histamine / pharmacology
Injections, Intra-Arterial
Mammary Arteries / drug effects*
Middle Aged
Muscle Contraction / drug effects*
Norepinephrine / pharmacology
Papaverine / administration & dosage*,  pharmacology
Potassium Chloride / pharmacology
Prostaglandin Endoperoxides, Synthetic / pharmacology
Serotonin / pharmacology
Thromboxane A2 / analogs & derivatives,  pharmacology
Time Factors
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Prostaglandin Endoperoxides, Synthetic; 0/Vasoconstrictor Agents; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 57576-52-0/Thromboxane A2; 58-74-2/Papaverine; 7447-40-7/Potassium Chloride; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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