| Effect of mode of application of papaverine on the contractile response of the internal mammary artery. | |
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MedLine Citation:
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PMID: 8205426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was performed to investigate the duration of action of papaverine applied either intraluminally or in a combined intraluminal and extraluminal fashion in vitro, and how the reactivity of the internal mammary artery (IMA) to a range of vasoconstrictors is affected. Segments of IMA exposed to only intraluminal papaverine (10(-4) mol/l) for 15 min recovered their contractile response to 90 mmol/l potassium chloride to pretreatment levels within 2 h. In contrast, combined intraluminal and extraluminal administration of papaverine resulted in a significant depression of the contractile response to 90 mmol/l potassium chloride (P < 0.001), which persisted for at least 5 h. Responses to 5-hydroxytryptamine, noradrenaline, the thromboxane mimetic U46619, histamine and dopamine were not significantly different between control tissues and those that had received intraluminal papaverine. The duration of action of papaverine is affected by its route of delivery and there are no significant short-term effects on the contractile mechanisms in the arterial wall after intraluminal administration. |
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Authors:
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A H Chester; R Panda; J A Borland; S Tadjkarimi; C J Schyns; G S O'Neil; M H Yacoub |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: The British journal of surgery Volume: 81 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-07-11 Completed Date: 1994-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 527-31 Citation Subset: AIM; IM |
Affiliation:
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National Heart and Lung Institute, Harefield Hospital, Middlesex, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Adult Aged Dopamine / pharmacology Dose-Response Relationship, Drug Histamine / pharmacology Humans Injections, Intra-Arterial Mammary Arteries / drug effects* Middle Aged Muscle Contraction / drug effects* Norepinephrine / pharmacology Papaverine / administration & dosage*, pharmacology Potassium Chloride / pharmacology Prostaglandin Endoperoxides, Synthetic / pharmacology Serotonin / pharmacology Thromboxane A2 / analogs & derivatives, pharmacology Time Factors Vasoconstrictor Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandin Endoperoxides, Synthetic; 0/Vasoconstrictor Agents; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 57576-52-0/Thromboxane A2; 58-74-2/Papaverine; 7447-40-7/Potassium Chloride; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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