Document Detail

Effect of mitomycin C and 60Co gamma-irradiation on the replication of SV40 in cell lines of varying permissivity for SV40 replication.
MedLine Citation:
PMID:  225419     Owner:  NLM     Status:  MEDLINE    
The effects of mitomycin C and 60Co gamma-irradiation, which induce production of SV40 from SV40-transformed hamster cells, on the replication of superinfecting SV40 or virus DNA in cells varying in permissivity for SV40 replication have been examined. These agents enhance replication of SV40 in an uninducible line of SV40-transformed hamster kidney cells and in nonpermissive secondary hamster kidney cells. The same treatments do not affect SV40 replication in semipermissive hamster (BHK21) and human (HEL, HEK) cells and inhibit SV40 replication in permissive monkey (TC-7) cells. We conclude that forms of induction treatment, such as mitomycin C or 60Co gamma-irradiation, modify the expression of host cell factors which determine the level of permissivity for SV40 infection.
T Rakusanova; W P Smales; J C Kaplan; P H Black
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of general virology     Volume:  43     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
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MeSH Terms
Cell Line
Clone Cells
Cobalt Radioisotopes*
Mitomycins / pharmacology*
Simian virus 40 / drug effects,  growth & development*,  radiation effects
Virus Replication* / drug effects,  radiation effects
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Mitomycins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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