Document Detail

Effect of minocycline on the sperm count and activity in infertile men with high pus cell count in their seminal fluid.
MedLine Citation:
PMID:  1479417     Owner:  NLM     Status:  MEDLINE    
Twenty-five infertile males with 5 or more pus cells per 1000 x field in their seminal fluid were randomly assigned to treatment with minocycline 200 mg daily for one (Group A) or two (Group B) weeks. At the end of the treatment period a statistically significant reduction of pus cells, and a statistically significant increase in the sperm count and the motile sperm were observed (Wilcoxon matched-pairs signed-ranks test, p < 0.01). No statistically significant differences were observed between the two groups (Mann Whitney U test). No toxicity was reported. In conclusion, minocycline improves the seminal indices, in infertile males with high pus cell count in their seminal fluid.
Y A Malallah; N P Zissis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  4     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-02-08     Completed Date:  1993-02-08     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  286-9     Citation Subset:  IM    
Al Sabah Hospital, Dermatology and Venereology Department, Kuwait.
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MeSH Terms
Chlamydia Infections / complications,  drug therapy
Chlamydia trachomatis
Drug Administration Schedule
Epididymitis / complications,  drug therapy
Infertility, Male / drug therapy*,  microbiology*
Minocycline / therapeutic use*
Semen / drug effects,  microbiology*
Sperm Count / drug effects*
Sperm Motility / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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