Document Detail


Effect of milrinone on short term outcome of patients with myocardial dysfunction undergoing off-pump coronary artery bypass graft: a randomized clinical trial.
MedLine Citation:
PMID:  24338139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial dysfunction is a major complication in cardiac surgery that needs inotropic support. This study evaluates the effect of milrinone on patients with low ventricular ejection fraction undergoing off- pump coronary artery bypass graft (OPCAB). The present study is designed to evaluate the effect of milrinone on myocardial dysfunction. Eighty patients with low ventricular ejection fraction (<35%), candidate for elective OPCAB, were enrolled in this study. They were randomly assigned to two groups. One group received milrinone (50 μg/kg) intravenously and another group received a saline as placebo followed by 24 hours infusion of each agent (0.5 μg/kg/min). Short outcome of patients such as hemodynamic parameters and left ventricular ejection fraction were variables evaluated. Serum levels of creatine phosphokinase, the MB isoenzyme of creatine kinase, occurrence of arrhythmias and mean duration of mechanical ventilation were significantly lower in milrinone group (P&lt;0.05). The mean post operative left ventricular ejection fraction was significantly higher in milrinone group (P=0.031). There were no statistical significant differences between the two groups in terms of intra-aortic balloon pump, inotropic support requirement, myocardial ischemia, myocardial infarction, duration of inotropic support, duration of intensive care unit stay, mortality and morbidity rate. Administration of milrinone in patients undergoing OPCAB with low ventricular ejection fraction is useful and effective.
Authors:
Mehdi Hadadzadeh; Seyed Habib Hosseini; Seyed Mohammad Yousof Mostafavi Pour Manshadi; Nafiseh Naderi; Mahmood Emami Meybodi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta medica Iranica     Volume:  51     ISSN:  1735-9694     ISO Abbreviation:  Acta Med Iran     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-16     Completed Date:  2014-07-30     Revised Date:  2014-09-30    
Medline Journal Info:
Nlm Unique ID:  14540050R     Medline TA:  Acta Med Iran     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  681-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiotonic Agents / therapeutic use*
Coronary Artery Bypass*
Double-Blind Method
Female
Humans
Male
Middle Aged
Milrinone / therapeutic use*
Myocardial Ischemia / drug therapy*,  physiopathology,  surgery*
Placebos
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Placebos; JU9YAX04C7/Milrinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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