Document Detail

Effect of mifepristone on pregnancy, pregnancy-specific protein B (PSPB), progesterone, estradiol-17beta, prostaglandin F2alpha (PGF2alpha) and prostaglandin E (PGE) in ovariectomized 90-day pregnant ewes.
MedLine Citation:
PMID:  12428689     Owner:  NLM     Status:  MEDLINE    
The objective of this experiment was to determine the effect of mifepristone, a progesterone receptor antagonist, on pregnancy and secretion of steroids, pregnancy-specific protein B (PSPB) and prostaglandins at mid-pregnancy in ewes. Ninety-day pregnant ewes were ovariectomized (OVX) and treatments were initiated 72 h post-OVX. Ewes received (1) vehicle, (2) prostaglandin F2alpha (PGF2alpha, 8 mg/58 kg/bw, i.m.) 84 h post-OVX, (3) mifepristone (50 mg intrajugular at 72, 84, 96, and 108 h post-OVX), (4) mifepristone (50mg) + PGF2alpha, (5) mifepristone (100 mg intrajugular at 72, 84, 96, and 108 h), and (6) mifepristone (100 mg) + PGF2alpha. Ewes treated with vehicle or PGF2alpha alone did not abort (P > or = 0.05). But, 60, 80, 60, and 100% of ewes treated with mifepristone (50 mg), mifepristone (50 mg) + PGF2alpha, mifepristone (100 mg), and mifepristone (100 mg) + PGF2alpha, respectively, aborted (P < or = 0.05). Profiles of progesterone, estradiol-17beta, prostaglandin E (PGE), or PSPB did not differ (P > or = 0.05) among treatment groups. Profiles of PGF2alpha of treatment groups receiving mifepristone with or without PGF2alpha differed (P < 0.05) from vehicle or PGF2alpha alone-treated ewes. It is concluded that progesterone actions are necessary to suppress uterine/placental secretion of PGF2alpha and that maintenance of critical progesterone: estradiol-17beta and PGE:PGF2alpha ratios are necessary for maintenance of pregnancy.
Y S Weems; P J Bridges; R G Sasser; L Ching; B R LeaMaster; D L Vincent; C W Weems
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  70     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-04-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-208     Citation Subset:  IM    
Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu 96822, USA.
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MeSH Terms
Abortion, Induced / veterinary
Aspartic Acid Endopeptidases / drug effects
Dinoprost / metabolism*
Estradiol / metabolism
Mifepristone / pharmacology*
Ovary / physiology*
Pregnancy Maintenance
Pregnancy Proteins / drug effects
Pregnancy, Animal / drug effects*
Prostaglandins E / metabolism
Receptors, Progesterone / antagonists & inhibitors*
Reg. No./Substance:
0/Pregnancy Proteins; 0/Prostaglandins E; 0/Receptors, Progesterone; 50-28-2/Estradiol; 551-11-1/Dinoprost; 84371-65-3/Mifepristone; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC 3.4.23.-/pregnancy-associated glycoprotein 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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