Document Detail


Effect of mifegin on the content of cyclic nucleotides in the cervical myometrium in full-term pregnancy.
MedLine Citation:
PMID:  12533756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cervical myometrium was examined in 22 pregnant women at 39-41 weeks gestation at risk of labor abnormalities. The patients received mifegin for preparing to labor. A new component in the mechanism of mifegin effect on the uterine cervix in full-term pregnancy was revealed: mifegin elevated the content of cAMP by 50% and almost 2-fold increased the cAMP/cGMP ratio compared to the initial level.
Authors:
P V Sergeev; E N Kareva; N D Gasparyan; V V Podval'nyuk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  134     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2003-01-20     Completed Date:  2003-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-50     Citation Subset:  IM    
Affiliation:
Department of Molecular Pharmacology, Russian State Medical University, Russia.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Cyclic AMP / metabolism*
Cyclic GMP / metabolism*
Drug Administration Schedule
Female
Humans
Labor, Obstetric / metabolism
Mifepristone / administration & dosage,  pharmacology*
Myometrium / drug effects,  metabolism*
Pregnancy / metabolism*
Pregnancy Outcome
Chemical
Reg. No./Substance:
60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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