| Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man. | |
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MedLine Citation:
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PMID: 341939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Mianserin seems to have little effect on peripheral noradrenaline (NA) re-uptake mechanisms as shown by its lack of effects on the tyramine dose and NA dose/pressor response. 2. Mianserin has no effect on the hypotensive action of bethanidine. 3. Mianserin in vivo has a significant action on platlet transport (Vmax) of 5-hydroxytryptamine (5-HT), which changes toward normal values in depressive patients on the drug. This action is not observed in vitro. 4. It is possible that a metabolite of mianserin is responsible for this effect, and that this may be of therapeutic importance. |
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Authors:
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A Coppen; K Ghose; C Swade; K Wood |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 5 Suppl 1 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1978 |
Date Detail:
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Created Date: 1978-04-17 Completed Date: 1978-04-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 13S-17S Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antidepressive Agents Bethanidine / antagonists & inhibitors Blood Platelets / metabolism Clinical Trials as Topic Depression / blood Dibenzazepines / pharmacology* Female Humans Hypertension / blood Male Mianserin / metabolism, pharmacology* Norepinephrine / metabolism* Placebos Serotonin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Dibenzazepines; 0/Placebos; 24219-97-4/Mianserin; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 55-73-2/Bethanidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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