Document Detail


Effect of mexiletine on reperfusion-induced ventricular arrhythmias: comparison with lidocaine.
MedLine Citation:
PMID:  3827408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty mongrel dogs underwent proximal occlusion of the left anterior descending coronary artery to evaluate the comparative action of mexiletine and lidocaine on ventricular arrhythmias during myocardial reperfusion. Heart rate, arterial blood pressure, left ventricular end-diastolic pressure and dp/dt max were evaluated before and at the 20th and 25th min after coronary occlusion; at the 25th min coronary occlusion was removed. Dogs were randomly assigned to one of the following groups of 10: 1) control group; 2) dogs given i.v. mexiletine; 3) dogs given i.v. lidocaine. As expected, during ischemia, myocardial contractility decreased after mexiletine or lidocaine administration more than in the control group. Ventricular arrhythmias during myocardial reperfusion occurred in 9 dogs of the control group (ventricular tachycardia in 2 cases and ventricular fibrillation in 7 cases). Among dogs given mexiletine only 1 had ventricular fibrillation (p less than 0.001 vs control). Six of the 10 dogs given lidocaine had ventricular arrhythmias (ventricular tachycardia in 5 cases and ventricular fibrillation in 1 case) (p = ns vs control group; p less than 0.05 vs mexiletine group). Thus mexiletine and lidocaine had similar effects on cardiac function during myocardial ischemia and only mexiletine showed a protective effect against reperfusion ventricular arrhythmias.
Authors:
D Bonaduce; N Ferrara; P Abete; G Longobardi; D Leosco; V Canonico; G Morgano; F Rengo
Related Documents :
2934968 - Echocardiographic evaluation of left ventricular function during coronary artery angiop...
7460198 - The effect of verapamil on mechanical performance of acutely ischemic and reperfused my...
21731608 - Hmgb1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regenera...
14744808 - Sildenafil (viagra) reduces arrhythmia severity during ischaemia 24 h after oral admini...
7971398 - Digital signal processing chip implementation for detection and analysis of intracardia...
16202368 - Myocardial ischaemia and reperfusion injury: reactive oxygen species and the role of ne...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  284     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-04-17     Completed Date:  1987-04-17     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  19-29     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / prevention & control*
Constriction
Coronary Circulation*
Coronary Vessels
Dogs
Female
Hemodynamics / drug effects
Lidocaine / therapeutic use*
Male
Mexiletine / therapeutic use*
Chemical
Reg. No./Substance:
137-58-6/Lidocaine; 31828-71-4/Mexiletine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Combined phenytoin and salicylate effects on thyroid function tests.
Next Document:  Tricyclic antidepressant inhibition of the electrical evoked responses of the rat urinary bladder st...