Document Detail

Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats.
MedLine Citation:
PMID:  23940444     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: To explore the effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization (CME) in rats.
METHODS: Forty rats were randomly divided into four groups (n=10 each): a sham operation (control) group, CME plus saline (CME) group, CME plus metoprolol (metoprolol) group and caspase-9 inhibitor Z-LEHD-FMK (ZLF) group. CME was induced by injecting 3000 polyethylene microspheres (42 μm diameter) into the left ventricle during a 10 s occlusion of the ascending aorta. Echocardiography, terminal deoxynucleotidyl transferase dUTP nick end labelling and Western blotting were used to evaluate cardiac function, apoptosis and activation of caspase-9/caspase-3, respectively, 6 h after CME.
RESULTS: The echocardiographic parameters of left ventricular function were significantly decreased in the CME group compared with the control group (P<0.05); however, the metoprolol group and ZLF group showed significantly improved cardiac function compared with CME alone (P<0.05). Compared with the control group, the myocardial apoptosis rate and the levels of activated caspase-9 and -3 increased significantly in the CME group (P<0.05). Again, these effects were ameliorated by metoprolol and ZLF (P<0.05).
CONCLUSIONS: The present study demonstrates that metoprolol and ZLF can protect the rat myocardium during CME by inhibiting apoptosis and improving cardiac function, likely by inhibiting apoptosis/ mitochondrial apoptotic pathway. These results suggest that antiapoptotic therapies may be useful in treating CME.
Qiang Su; Lang Li; Yang-Chun Liu; You Zhou; Yong-Guang Lu; Wei-Ming Wen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and clinical cardiology     Volume:  18     ISSN:  1205-6626     ISO Abbreviation:  Exp Clin Cardiol     Publication Date:  2013  
Date Detail:
Created Date:  2013-08-13     Completed Date:  2013-08-13     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  9715903     Medline TA:  Exp Clin Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  -    
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
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