| Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial. | |
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MedLine Citation:
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PMID: 11511433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Beta-blockade usually causes a slight reduction in exercise capacity among healthy subjects, while more variable results have been observed in chronic heart failure (CHF), probably related to patients studied, methods and agent used. The effect of metoprolol controlled release/extended release (CR/XL) on peak oxygen uptake (peak VO(2)) in this patient population has not previously been investigated. AIMS: We examined the effect of long-term treatment with the selective beta(1)-receptor blocker metoprolol CR/XL once daily on exercise capacity in patients with CHF. METHODS: Ninety-four patients (70 males and 24 females; mean age 63.6+/-10.6 years) with chronic symptomatic heart failure in New York Heart Association (NYHA) functional class II-IV, and with ejection fraction <or=40%, stabilized on optimum standard therapy were randomized to metoprolol CR/XL or placebo in a double-blind trial. Exercise capacity was evaluated by peak VO(2) at baseline, after 3 months and at the end of study (mean follow-up 11.4+/-0.4 months). RESULTS: Compared with placebo metoprolol CR/XL produced a significant decrease in heart rate by 11 beats/min at rest and 18 beats/min at peak exercise. There was a tendency for a temporal decline in peak VO(2) after 3 months of therapy in both groups, but altogether peak VO(2) remained unchanged from baseline with no difference between the groups at 1 year. CONCLUSIONS: In patients with moderate to severe CHF, 11.4 months of beta(1)-blockade with metoprolol CR/XL had no effect on exercise capacity when compared with placebo or baseline. |
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Authors:
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L Gullestad; C Manhenke; T Aarsland; R Skårdal; H Fagertun; J Wikstrand; J Kjekshus |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of heart failure Volume: 3 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-20 Completed Date: 2001-10-18 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 463-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Division of Heart and Lung Diseases, Rikshospitalet, 0027 Oslo, Norway. lagulles@online.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chronic Disease Confidence Intervals Delayed-Action Preparations Double-Blind Method Drug Administration Schedule Exercise Tolerance / drug effects* Female Follow-Up Studies Heart Failure / drug therapy*, physiopathology Heart Function Tests Hemodynamics / drug effects Humans Long-Term Care Male Metoprolol / administration & dosage* Middle Aged Oxygen Consumption / physiology Probability Reference Values Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 37350-58-6/Metoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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