Document Detail

Effect of methylglyoxal bis(guanylhydrazone) on polyamine metabolism in normal and regenerating rat liver and rat thymus.
MedLine Citation:
PMID:  4205354     Owner:  NLM     Status:  MEDLINE    
1. Injections of sublethal doses of methylglyoxal bis(guanylhydrazone), a potent inhibitor of putrescine-activated S-adenosylmethionine decarboxylase in vitro, resulted after a few days in an immense increase in the activity of S-adenosylmethionine decarboxylase in normal and regenerating rat liver and in rat thymus. The increase in the activity of S-adenosylmethionine decarboxylase was at least partly due to a marked lengthening of the half-life of the enzyme. 2. In regenerating liver and thymus there was also a moderate stimulation of the activity of ornithine decarboxylase (EC and a marked accumulation of tissue putrescine. 3. Injection of methylglyoxal bis(guanylhydrazone) into the rat also markedly decreased the activity of diamine oxidase (EC in thymus. 4. In no cases where doses of methylglyoxal bis(guanylhydrazone) close to the LD(50) dose for the rat were used was it possible to lower tissue spermidine content to any significant extent. 5. Methylglyoxal bis(guanylhydrazone) seemed to act as a competitive inhibitor for the substrate S-adenosylmethionine and as an uncompetitive inhibitor for the activator putrescine in the decarboxylation of S-adenosylmethionine in vitro. 6. In the diamine oxidase reaction, with putrescine as the substrate, methylglyoxal bis(guanylhydrazone) was a non-competitive inhibitor for putrescine.
E Hölttä; P Hannonen; J Pispa; J Jänne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  136     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1973 Nov 
Date Detail:
Created Date:  1974-04-25     Completed Date:  1974-04-25     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  669-76     Citation Subset:  IM    
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MeSH Terms
Aldehydes / pharmacology*
Amidines / pharmacology*
Amine Oxidase (Copper-Containing) / metabolism
Carbon Radioisotopes
Carboxy-Lyases / antagonists & inhibitors
Glyoxal / pharmacology
Hydrazones / pharmacology
Lethal Dose 50
Liver / enzymology,  metabolism*
Liver Regeneration*
Polyamines / metabolism*
Spermidine / metabolism
Thymus Gland / enzymology,  metabolism*
Reg. No./Substance:
0/Aldehydes; 0/Amidines; 0/Carbon Radioisotopes; 0/Hydrazones; 0/Polyamines; 107-22-2/Glyoxal; 110-60-1/Putrescine; 124-20-9/Spermidine; 29908-03-0/S-Adenosylmethionine; 7006-33-9/Ornithine; EC Oxidase (Copper-Containing); EC 4.1.1.-/Carboxy-Lyases

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