Document Detail

Effect of methylene blue on refractory neonatal hypotension.
MedLine Citation:
PMID:  8969734     Owner:  NLM     Status:  MEDLINE    
Excess nitric oxide is a mediator of the hypotension in septic shock. Nitric oxide dilates vascular smooth muscle through activation of soluble guanylate cyclase. We report the increase in blood pressure caused by methylene blue (MB), a soluble guanylate cyclase inhibitor, in five neonates with presumed septic shock unresponsive to colloids, inotropic agents, and corticosteroids. MB was given intravenously at a dose of 1 mg/kg during a 1-hour period. MB increased blood pressure in each patient (average, 33% +/- 20%). Blood pressure subsequently decreased to near baseline values in three patients, who then received a second infusion of MB. Blood pressure again increased in these patients. Three of five patients were weaned from inotropic support within 72 hours. Three of five patients survived and were discharged home. We suggest that MB increased blood pressure in these neonates with refractory hypotension.
W Driscoll; S Thurin; V Carrion; R H Steinhorn; F C Morin
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  129     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-16     Completed Date:  1997-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  904-8     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Buffalo, New York, USA.
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MeSH Terms
Blood Pressure / drug effects
Diseases in Twins
Drug Evaluation
Heart Rate / drug effects
Hypotension / blood,  drug therapy*,  physiopathology
Infant, Newborn
Infant, Premature
Infusions, Intravenous
Methylene Blue / administration & dosage*
Nitric Oxide / antagonists & inhibitors
Shock, Septic / blood,  drug therapy,  physiopathology
Reg. No./Substance:
10102-43-9/Nitric Oxide; 61-73-4/Methylene Blue
Comment In:
J Pediatr. 1996 Dec;129(6):790-3   [PMID:  8969718 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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