Document Detail

Effect of methotrexate on tubal epithelium. A report of three cases.
MedLine Citation:
PMID:  9987739     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tubal effects of methotrexate injections have been poorly reported. CASES: Three fallopian tubes were examined with light microscopy 9-13 months after tubal methotrexate injection (one case) and intramuscular methotrexate injection (two cases) given for the treatment of unruptured ectopic pregnancies. No evidence of tubal damage was found. CONCLUSION: These three cases confirm previous experimental and clinical data showing the absence of a direct adverse effect of methotrexate on the fallopian tubes in the treatment of ectopic pregnancy.
F Lécuru; F Robin; R Taurelle; J P Bernard; F Vildé
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  44     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-29     Completed Date:  1999-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-8     Citation Subset:  IM    
Gynecologic and Obstetric Service, Boucicaut Hospital, Paris, France.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage,  pharmacology*,  therapeutic use
Epithelium / drug effects
Fallopian Tubes / drug effects*,  pathology
Injections, Intramuscular
Methotrexate / administration & dosage,  pharmacology*,  therapeutic use
Pregnancy, Tubal / drug therapy*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

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