Document Detail

Effect of methotrexate treatment of ectopic pregnancy on subsequent pregnancy.
MedLine Citation:
PMID:  21252128     Owner:  NLM     Status:  MEDLINE    
QUESTION: My last pregnancy was diagnosed as ectopic, and I was treated successfully with intramuscular methotrexate (MTX) 8 weeks ago. I am currently planning for another pregnancy; however, I have read that MTX causes birth defects and that it stays in my body for a very long time, ranging from 1 to 12 months after treatment. When is it safe to conceive?
ANSWER: We suggest that the outcomes of pregnancies conceived shortly after MTX therapy for extrauterine pregnancy are most likely to be favourable and similar to those pregnancies conceived 6 months after MTX treatment. However, as data are not sufficient to draw a definitive conclusion or to confirm the exact safe timing after MTX treatment, at least a 3-month waiting period is recommended for women who are planning pregnancy. Nevertheless, conception within 3 months of MTX treatment of extrauterine pregnancy should not be considered a definite indication of termination, and further targeted fetal anatomy assessment is recommended. Further retrospective and prospective studies are needed to define the safety period before 3 months and to solidify this recommendation.
Rinat Hackmon; Sachi Sakaguchi; Gideon Koren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  57     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-21     Completed Date:  2012-04-26     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  37-9     Citation Subset:  IM    
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MeSH Terms
Abortifacient Agents, Nonsteroidal / adverse effects*,  therapeutic use
Fertilization / drug effects
Maternal Exposure* / adverse effects
Methotrexate / adverse effects*,  therapeutic use
Preconception Care*
Pregnancy, Ectopic / drug therapy*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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