Document Detail

Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats.
MedLine Citation:
PMID:  15182389     Owner:  NLM     Status:  MEDLINE    
The objectives of the present study were to evaluate the effects of a methionine-supplemented diet on systolic blood pressure (BP) and vasomotor functions in Sprague-Dawley (SD) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. SD and DOCA rats were fed a normal or a methionine (8 g/kg)-supplemented diet for 10 weeks. Systolic BP was monitored and plasma homocysteine, methionine and cysteine levels were determined at the end of the experiment. Vasoconstriction and vasodilatation of aortic rings were measured. The methionine-supplemented diet induced a greater increase in homocysteinaemia concentration in DOCA rats than in SD rats and an increase in plasma cysteine concentration in DOCA rats. This diet was associated with an increase in systolic BP in SD rats and with a lesser development of DOCA-salt hypertension. An enhanced aortic constriction and a decreased responsiveness to acetylcholine, bradykinin and sodium nitroprusside in the SD rats fed the methionine-rich diet were consistent with the elevated systolic BP. In DOCA rats the increased responsiveness to bradykinin was in accordance with the systolic BP-lowering effect. In conclusion, the methionine-enriched diet cannot simply be considered as model of hyperhomocysteinaemia, since other metabolites and mechanisms seemed to be implicated in these complex interactions. The differential vasopressive effect of the methionine supplementation in SD and DOCA rats, and in particular the lowering of systolic BP obtained with a greater degree of hyperhomocysteinaemia in DOCA rats, suggest that more complex interactions exist between hyperhomocysteinaemia and BP than the simple positive association described previously.
Sophie Robin; Véronique Maupoil; Pascal Laurant; Alain Jacqueson; Alain Berthelot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  91     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-08     Completed Date:  2004-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  857-65     Citation Subset:  IM    
Laboratoire de Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, Cedex, France.
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MeSH Terms
Acetylcholine / pharmacology
Aorta / drug effects
Blood Pressure / drug effects*
Body Weight / drug effects
Bradykinin / pharmacology
Calcium Chloride / pharmacology
Cysteine / blood
Dietary Supplements*
Glutathione / blood
Homocysteine / blood
Hypertension / blood,  chemically induced,  physiopathology*
Methionine / administration & dosage*,  blood
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Organ Size / drug effects
Rats, Sprague-Dawley
Sodium / metabolism
Vasoconstrictor Agents / administration & dosage*
Reg. No./Substance:
0/Vasoconstrictor Agents; 10043-52-4/Calcium Chloride; 15078-28-1/Nitroprusside; 454-28-4/Homocysteine; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 52-90-4/Cysteine; 58-82-2/Bradykinin; 63-68-3/Methionine; 64-85-7/Desoxycorticosterone; 70-18-8/Glutathione; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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