Document Detail

Effect of metallothionein I on mitochondrial oxygen consumption.
MedLine Citation:
PMID:  8007764     Owner:  NLM     Status:  MEDLINE    
The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied. Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT. The MT effect was concentration dependent. No evidence was found for the provision by MT of an alternate pathway to oxygen.
C O Simpkins; H L Zhao; C A Torrence
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  55     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1994  
Date Detail:
Created Date:  1994-07-19     Completed Date:  1994-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
University of Maryland School of Medicine, Department of Surgery, Baltimore.
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MeSH Terms
Adenosine Diphosphate / metabolism
Cadmium / pharmacology
Cadmium Chloride
Chlorides / pharmacology
Dose-Response Relationship, Drug
Electron Transport / drug effects
Metallothionein / pharmacology*
Mitochondria, Liver / drug effects,  metabolism*
Oxygen Consumption / drug effects*
Rats, Sprague-Dawley
Succinates / metabolism
Succinic Acid
Zinc Compounds / pharmacology
Reg. No./Substance:
0/Chlorides; 0/Succinates; 0/Zinc Compounds; 10108-64-2/Cadmium Chloride; 110-15-6/Succinic Acid; 58-64-0/Adenosine Diphosphate; 7440-43-9/Cadmium; 7646-85-7/zinc chloride; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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