Document Detail

Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn.
MedLine Citation:
PMID:  1607227     Owner:  NLM     Status:  MEDLINE    
Proteinase inhibitors have been shown to prevent corneal ulceration and perforation when used immediately after an experimental alkali burn injury. To evaluate the clinical efficacy of a synthetic metalloproteinase inhibitor, HSCH2CH[CH2CH(CH3)2]CO-Phe-Ala-NH2(SIMP), treatment with inhibitor was withheld until corneal ulceration ensued after a standard alkali injury to the rabbit eye. When topical therapy with a 1 mmol/l solution of SIMP was initiated after corneal ulceration had progressed to a mid-stromal level (clinical score of 2), there was no significant difference in the progression of corneal ulceration between the treated vs. control group after 6 d of therapy. In the second study in which treatment was initiated earlier at the onset of superficial ulceration (clinical score of 1), there was a significant difference in clinical scores between the two groups after 1 day of treatment until termination of the experiment at 21 d (P less than 0.005). In the inhibitor-treated group, 88.9% of the corneas showed a reversal or cessation of progression of the ulceration process. Eighty-seven-and-a-half percent of the control corneas progressed to descemetocele formation or perforation by day 14 of treatment. This study suggests that SIMP may be used for effective treatment of corneal ulcers resulting from an alkali burn injury in the human eye. It also shows that early and aggressive initiation of therapy is critical.
J S Wentworth; C A Paterson; R D Gray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  33     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-21     Completed Date:  1992-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2174-9     Citation Subset:  IM    
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky.
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MeSH Terms
Administration, Topical
Burns, Chemical / drug therapy*,  pathology
Corneal Ulcer / drug therapy*,  pathology
Dipeptides / therapeutic use*
Disease Models, Animal
Eye Burns / drug therapy*,  pathology
Metalloendopeptidases / antagonists & inhibitors*
Reg. No./Substance:
0/Dipeptides; 0/HSCH2CH(CH2CH(CH3)2)CO-Phe-Ala-NH2; EC 3.4.24.-/Metalloendopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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