Document Detail

Effect of metalloproteinase inhibitor on early postinfarction remodeling in the most acute phase of myocardial infarction.
MedLine Citation:
PMID:  24319718     Owner:  NLM     Status:  In-Data-Review    
Echocardiography in control narcotized rats (n=12) revealed that acute single-stage ligation of coronary artery induced a rapid and significant decrease in systolic function of the heart, which attained minimum to postischemic minutes 10-20 and then gradually restored during 60 min after coronary occlusion. Matrix proteinase inhibitor doxycycline (40 mg/kg/day intragastrically for 3 days prior to the experiment) prevented dramatic impairment of systolic function in the left ventricle during first 20 min of ischemia and then all the indices characterizing the state of pumping function of the left ventricle in the experimental (doxycycline) group (n=9) surpassed the control. Thus, matrix proteinase inhibitor doxycycline prevented early postischemic remodeling of the heart during the most acute phase of experimental myocardial infarction.
S A Kryzhanovskii; E O Ionova; V N Stolyaruk; I B Tsorin; M B Vititnova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  156     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-12-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  19-24     Citation Subset:  IM    
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
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