Document Detail


Effect of mercurascan on the contractility and excitability of dog papillary muscle in vitro.
MedLine Citation:
PMID:  3743090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors studied in 6 experimental series the effect of Mercurascan (2-hydromercurifluorescein and 4-hydroxymercurifluorescein) on isolated dog papillary muscle in vitro; they evaluated the magnitude and character of its electrically stimulated contractions. It was found that at concentration of 10(-3)M and 10(-4) M, Mercurascan (MSC) exerts a significant positive inotropic effect on papillary muscle. Incubation of the muscle in a medium containing MSC at the above-given concentrations significantly suppressed the positive inotropic and arrhythmogenic effect of adrenalin, added in an over-threshold dose into the nutrient medium.
Authors:
E Zdráhalová; M Vrána; P Málek; J Kolc; J Ratuský
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  28     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1986  
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  217-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catecholamines / pharmacology
Dogs
Drug Interactions
Epinephrine / antagonists & inhibitors
Fluoresceins / pharmacology*
Myocardial Contraction / drug effects*
Organomercury Compounds / pharmacology*
Papillary Muscles / drug effects*,  physiology
Stimulation, Chemical
Time Factors
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Fluoresceins; 0/Organomercury Compounds; 50922-49-1/mercurascan; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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