Document Detail

Effect of meperidine on oxygen consumption, carbon dioxide production, and respiratory gas exchange in postanesthesia shivering.
MedLine Citation:
PMID:  3111305     Owner:  NLM     Status:  MEDLINE    
Meperidine has been used to suppress postanesthesia shivering. However, its efficacy to date has only been assessed by observation of visible shivering. We measured the effect of meperidine on oxygen consumption (VO2), carbon dioxide production (VCO2) and pulmonary gas exchange in 14 otherwise healthy patients shivering after general anesthesia. Meperidine successfully suppressed visible shivering in all patients and was associated with significant decreases in VO2, and VCO2 and minute ventilation (VE) but not with return to basal levels. Arterial PCO2 levels remained unchanged at normal, whereas significant improvements occurred in pH and bicarbonate levels. Meperidine is an effective method of reducing the elevated metabolic demand of shivering.
P E Macintyre; E G Pavlin; J F Dwersteg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  66     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-24     Completed Date:  1987-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  751-5     Citation Subset:  AIM; IM    
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MeSH Terms
Acidosis / drug therapy
Anesthesia, General / adverse effects*
Carbon Dioxide / metabolism*
Meperidine / pharmacology*,  therapeutic use
Oxygen Consumption / drug effects*
Pulmonary Gas Exchange / drug effects*
Shivering / drug effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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