Document Detail


Effect of menopausal status on body composition and abdominal fat distribution.
MedLine Citation:
PMID:  10702775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Preliminary studies suggest that the menopause transition is associated with deleterious changes in body composition and abdominal fat distribution. Limitations of the methodology used in these studies, however, render their conclusions controversial. Thus, the present study used radiologic imaging techniques to examine the effect of menopausal status on body composition and abdominal fat distribution. DESIGN: Cross-sectional. SUBJECTS: Fifty-three healthy, middle-aged, premenopausal women (mean+/-SD; 47+/-3 y) and 28 early-postmenopausal women (51+/-4 y). MEASUREMENTS: Total and regional body composition by dual energy X-ray absorptiometry and abdominal fat distribution by computed tomography. RESULTS: No differences in total body fat-free mass or appendicular skeletal muscle mass were noted between groups. In contrast, total body fat mass was 28% higher (23+/-7 vs 18+/-7 kg) and percentage fat 17% higher (35+/-6 vs 30+/-9%; both P<0.01) in postmenopausal women compared with premenopausal women. Postmenopausal women had a 49% greater intra-abdominal (88+/-32 vs 59+/-32 cm2; P<0.01) and a 22% greater abdominal subcutaneous fat area (277+/-93 vs 227+/-108 cm2; P<0.05) compared to premenopausal women. The menopause-related difference in intra-abdominal fat persisted (P<0.05) after statistical adjustment for age and total body fat mass, whereas no difference in abdominal subcutaneous fat was noted. A similar pattern of differences in total and abdominal adiposity was noted in sub-samples of pre- and postmenopausal women matched for age or fat mass. CONCLUSION: Our data suggest that early-postmenopausal status is associated with a preferential increase in intra-abdominal fat that is independent of age and total body fat mass. International Journal of Obesity (2000) 24, 226-231
Authors:
M J Toth; A Tchernof; C K Sites; E T Poehlman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  24     ISSN:  0307-0565     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-06-06     Completed Date:  2000-06-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  226-31     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology and Metabolic Research, Department of Medicine and Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA.
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MeSH Terms
Descriptor/Qualifier:
Abdomen
Absorptiometry, Photon
Adipose Tissue / pathology*,  radiography
Adult
Body Composition*
Female
Humans
Menopause*
Middle Aged
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
AG13978/AG/NIA NIH HHS; AG151121/AG/NIA NIH HHS; M01RR1093252/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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