Document Detail

Effect of membrane fatty acid composition on radiosensitivity of V79 Chinese hamster cells.
MedLine Citation:
PMID:  3942776     Owner:  NLM     Status:  MEDLINE    
Exponentially growing V79-379A Chinese hamster fibroblasts were transferred to low-lipid medium enriched with a single fatty acid of the C18 series. After 24 h at 37 degrees C, the fatty acid composition was determined by gas chromatography of the corresponding methyl esters for the total lipid extracts of the cells and for the nuclear membrane fraction. Radiation survival curves, based upon a clonogenic assay, were obtained by irradiation with low dose-rate 60Co gamma rays at either 4 degrees C or room temperature. We observe no effect of fatty acid upon radiosensitivity of these cells at either temperature, in confirmation of published reports with other mammalian cell lines.
D L Goulet; G J Fisher; R Pageau; J E van Lier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  875     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-19     Completed Date:  1986-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  414-7     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cobalt Radioisotopes
Fatty Acids / analysis*
Fibroblasts / analysis,  radiation effects
Lung / analysis,  radiation effects
Membrane Lipids / analysis*
Time Factors
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Fatty Acids; 0/Membrane Lipids

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