Document Detail

Effect of melatonin on two stage skin carcinogenesis in Swiss mice.
MedLine Citation:
PMID:  11208355     Owner:  NLM     Status:  MEDLINE    
Melatonin, a hormone secreted by the pineal gland, is known to have anti-mutagenic and oncostatic actions. This beneficial action of melatonin has been explained in terms of its ability to scavenge free radicals and augment the activities of anti-oxidant enzymes. In the present study, we evaluated the effect of melatonin on benzo(a)pyrene-induced two stage skin carcinogenesis in mice and observed that it can not only decrease the number of animals bearing papillomas but also the number of papillomas per animal both in the initiation and promotion stages of skin carcinogenesis. It was also found that melatonin treated animals have low levels of lipid peroxides and that it can also prevent the binding of BP or its metabolites to DNA. In view of these evidence, it can be suggested that melatonin may function as an endogenous anti-mutagenic and oncostatic agent.
C A Kumar; U N Das
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  6     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2001-03-05     Completed Date:  2001-03-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  471-5     Citation Subset:  IM    
EFA Sciences LLC, Norwood, Massachusets, USA.
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MeSH Terms
Anticarcinogenic Agents / pharmacology*
Benzo(a)pyrene / toxicity
Croton Oil / toxicity
DNA / biosynthesis
Melatonin / pharmacology*
Papilloma / chemically induced,  pathology*,  prevention & control
Skin / drug effects,  metabolism,  pathology
Skin Neoplasms / chemically induced,  pathology*,  prevention & control*
Thymidine / metabolism
Reg. No./Substance:
0/Anticarcinogenic Agents; 50-32-8/Benzo(a)pyrene; 50-89-5/Thymidine; 73-31-4/Melatonin; 8001-28-3/Croton Oil; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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