Document Detail

Effect of melatonin on neurobehavioral dysfunctions induced by intrauterine hypoxia in rats.
MedLine Citation:
PMID:  15141968     Owner:  NLM     Status:  MEDLINE    
Intrauterine hypoxia associated with oxidative stress represents an important risk factor for development of neurobehavioral dysfunctions. In the present study, we investigated the potential protective effect of melatonin (MEL) on neurobehavioral dysfunctions induced by chronic intrauterine hypoxia in rats by the anticonvulsant drug phenytoin (PHT), which is known by its teratogenic potential. Pregnant female rats (Wistar/DV) were orally treated by PHT (150 mg/kg) from day 7 to 18 of gestation. MEL was dissolved in drinking water (40 microg/ml) and administered from day 0 to 19 of gestation. Neurobehavioral development of offspring was evaluated from birth up to day 90 of postnatal life. The results of the study confirmed the high behavior-teratogenic potential of PHT. Prenatal administration of PHT resulted in delayed neuromotor and reflex development, decreased exploration in the open field, abnormal "circling" and impaired performaces in water maze. Co-administration of MEL failed to have any effect on neurobehavioral dysfunctions induced by PHT treatment. Even administration of MEL alone caused developmental alterations in offspring manifested by accelerated testes descent and delayed onset of negative geotaxia and startle reflex. The results suggest to pay increased attention to MEL concerning its exogenous use during pregnancy.
M Dubovický; E Ujházy; P Kovacovský; J Navarová; M Juráni; L Soltés
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Central European journal of public health     Volume:  12 Suppl     ISSN:  1210-7778     ISO Abbreviation:  Cent. Eur. J. Public Health     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-14     Completed Date:  2004-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9417324     Medline TA:  Cent Eur J Public Health     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S23-5     Citation Subset:  IM    
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
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MeSH Terms
Analysis of Variance
Anoxia / chemically induced*
Behavior, Animal / drug effects*
Melatonin / pharmacology*
Oxidative Stress
Phenytoin / toxicity*
Prenatal Exposure Delayed Effects*
Psychomotor Disorders / chemically induced*
Rats, Wistar
Reg. No./Substance:
57-41-0/Phenytoin; 73-31-4/Melatonin

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