Document Detail


Effect of melatonin on neurobehavioral dysfunctions induced by intrauterine hypoxia in rats.
MedLine Citation:
PMID:  15141968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrauterine hypoxia associated with oxidative stress represents an important risk factor for development of neurobehavioral dysfunctions. In the present study, we investigated the potential protective effect of melatonin (MEL) on neurobehavioral dysfunctions induced by chronic intrauterine hypoxia in rats by the anticonvulsant drug phenytoin (PHT), which is known by its teratogenic potential. Pregnant female rats (Wistar/DV) were orally treated by PHT (150 mg/kg) from day 7 to 18 of gestation. MEL was dissolved in drinking water (40 microg/ml) and administered from day 0 to 19 of gestation. Neurobehavioral development of offspring was evaluated from birth up to day 90 of postnatal life. The results of the study confirmed the high behavior-teratogenic potential of PHT. Prenatal administration of PHT resulted in delayed neuromotor and reflex development, decreased exploration in the open field, abnormal "circling" and impaired performaces in water maze. Co-administration of MEL failed to have any effect on neurobehavioral dysfunctions induced by PHT treatment. Even administration of MEL alone caused developmental alterations in offspring manifested by accelerated testes descent and delayed onset of negative geotaxia and startle reflex. The results suggest to pay increased attention to MEL concerning its exogenous use during pregnancy.
Authors:
M Dubovický; E Ujházy; P Kovacovský; J Navarová; M Juráni; L Soltés
Related Documents :
8141418 - Effect of acute hypoxia on phosphate excretion in rats.
10415538 - Activity of cytochrome c oxidase in the right and left ventricular myocardium of male a...
3809758 - The hypoxic ventilatory response of rats with increased blood oxygen affinity.
152938 - Thallium-201: quantitation of right ventricular hypertrophy in chronically hypoxic rats.
479728 - Oestrogenic effects of catechol oestrogens on secretion of prolactin by the pituitary g...
8445208 - Effects of terlipressin on hemodynamics and oxygen content in conscious portal vein ste...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Central European journal of public health     Volume:  12 Suppl     ISSN:  1210-7778     ISO Abbreviation:  Cent. Eur. J. Public Health     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-14     Completed Date:  2004-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9417324     Medline TA:  Cent Eur J Public Health     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S23-5     Citation Subset:  IM    
Affiliation:
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic. exfadubm@savba.sk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anoxia / chemically induced*
Behavior, Animal / drug effects*
Female
Melatonin / pharmacology*
Oxidative Stress
Phenytoin / toxicity*
Pregnancy
Prenatal Exposure Delayed Effects*
Psychomotor Disorders / chemically induced*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
57-41-0/Phenytoin; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of bronchoalveolar lavage fluid cytotoxic parameters after inhalation exposure to amosite...
Next Document:  The effect of estradiol on the oxidative damage and trace element level determined in the liver of r...