Document Detail

Effect of melatonin on cholesterol absorption in rats.
MedLine Citation:
PMID:  17349025     Owner:  NLM     Status:  MEDLINE    
This study evaluated the influence of melatonin on cholesterol absorption in rats fed on high cholesterol diet (HCD). HCD induced a remarkable increase in hepatic and plasma total cholesterol, plasma very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol, a decrease in high density lipoprotein (HDL) cholesterol and an elevation in triacylglyceride (TG) levels in plasma and in the liver. Melatonin suspension (10 mg/kg), specially prepared for this purpose, cholestyramine (230 mg/kg) and ezetimibe (145 microg/kg) were administered orally to the rats fed HCD for 30 days. Melatonin significantly reduced cholesterol absorption in rats fed on HCD and caused significant decreases in total cholesterol, TG, VLDL- and LDL-cholesterol in the plasma and contents of cholesterol and TG in the liver. The level of HDL cholesterol was significantly increased after melatonin. These results suggested that inhibition of cholesterol absorption caused by melatonin could be a mechanism contributing to the positive changes in plasma cholesterol, lipoprotein profile and the lipid contents in the liver.
Saad Abdul-Rehman Hussain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pineal research     Volume:  42     ISSN:  0742-3098     ISO Abbreviation:  J. Pineal Res.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-06-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
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MeSH Terms
Anticholesteremic Agents / pharmacology
Azetidines / pharmacology
Cholesterol / blood,  metabolism*
Cholestyramine Resin / pharmacology
Intestinal Absorption / drug effects*
Liver / metabolism*
Melatonin / pharmacology*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Azetidines; 11041-12-6/Cholestyramine Resin; 163222-33-1/ezetimibe; 57-88-5/Cholesterol; 73-31-4/Melatonin

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