Document Detail

Effect of melafen on structure and function of liposome and ehrlich ascitic carcinoma cell membranes.
MedLine Citation:
PMID:  19902072     Owner:  NLM     Status:  MEDLINE    
The effects of melafen (plant growth stimulant) on membrane structure and functions of animal cells were studied. The process of signal transduction from cell surface to intracellular structures and conformation changes in membranes in the presence of this substance were studied by light scatter and differential scanning microcalorimetry. Melafen in a wide range of concentrations (10(-13)-10(-3) M) inhibited Ca(2+) signal system involved in the function of Ca(2+)-dependent K(+) and Cl(-) channels in Ehrlich ascitic carcinoma cells. Being a hydrophilic substance, melafen had little effect on the lipid phase of artificial membranes, but impaired the function state of transformed cell. The importance of studies of transformed cells causes no doubt because of increasing incidence of diseases associated with uncontrolled cell division.
O M Alekseeva; L D Fatkullina; Yu A Kim; E B Burlakova; S G Fattakhov; A N Goloshchapov; A I Konovalov
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  147     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-11-10     Completed Date:  2010-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-5     Citation Subset:  IM    
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
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MeSH Terms
Calcium / metabolism
Carcinoma, Ehrlich Tumor / metabolism*
Cell Membrane / drug effects*,  metabolism
Chloride Channels / drug effects
Dimyristoylphosphatidylcholine / chemistry
Liposomes / chemistry*
Membranes, Artificial
Molecular Structure
Phosphinic Acids / chemistry,  pharmacology*
Potassium Channels / drug effects
Signal Transduction / drug effects
Triazines / chemistry,  pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Chloride Channels; 0/Liposomes; 0/Membranes, Artificial; 0/Phosphinic Acids; 0/Potassium Channels; 0/Triazines; 0/melaphene; 13699-48-4/Dimyristoylphosphatidylcholine; 7440-70-2/Calcium

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