| Effect of medical and surgical treatment of Barrett's metaplasia. | |
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MedLine Citation:
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PMID: 20698039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Barrett's esophagus (BE) is a change in the esophageal mucosa as a result of long-standing gastroesophageal reflux disease. The importance of BE is that it is the main risk factor for the development of esophageal adenocarcinoma, whose incidence is currently growing faster than any other cancer in the Western world. The aim of this review was to compare the common treatment modalities of BE, with the focus on proton pump inhibitors and operative fundoplication. We performed a literature search on medical and surgical treatment of BE to determine eligible studies for this review. Studies on medical and surgical treatment of BE are discussed with regard to treatment effect on progression and regression of disease. Although there is some evidence for control of reflux with either medical or surgical therapy, there is no definitive evidence that either treatment modality decreases the risk of progression to dysplasia or cancer. Even though there is a trend toward antireflux surgery being superior, there are no definitive studies to prove this. |
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Authors:
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Eelco B Wassenaar; Brant K Oelschlager |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 3773-9 Citation Subset: IM |
Affiliation:
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Center for Videoendoscopic Surgery, Department of Surgery, University of Washington, Seattle, WA 98195, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Barrett Esophagus
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pathology,
therapy* Disease Progression Esophageal Neoplasms / pathology, prevention & control* Esophagus / pathology, surgery* Fundoplication* Humans Metaplasia Precancerous Conditions / pathology, therapy* Proton Pump Inhibitors / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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