Document Detail

Effect of medial arterial calcification on O2 supply to exercising diabetic feet.
MedLine Citation:
PMID:  2373265     Owner:  NLM     Status:  MEDLINE    
We investigated whether medial arterial calcification (MAC) impairs O2 supply to the exercising foot in diabetic patients with foot lesions. Transcutaneous O2 tension (tcPO2) was monitored at the dorsum of the foot before and after bicycle exercise in 11 diabetic patients with peripheral ischemic vascular disease (PIVD) with or without concomitant existence of MAC, 10 patients with MAC but without PIVD, 10 diabetic control subjects, and 6 nondiabetic control subjects. The mean preexercise tcPO2 level was comparable in these four groups. However, tcPO2 decreased significantly with exercise in feet with PIVD (mean +/- SE -17.9 +/- 2.7%, P less than 0.01, n = 11), regardless of presence or absence of vascular calcification. On the other hand, the value increased significantly with exercise in feet with MAC but without PIVD (21.2 +/- 3.5%, P less than 0.01, n = 10) and in those of diabetic control subjects (14.9 +/- 3.6%, P less than 0.01), respectively. The tcPO2 remained unchanged in the feet of nondiabetic control subjects (1.7 +/- 1.1%). The results suggest that MAC is not associated with reduced O2 supply to the exercising foot in diabetic patients.
E Chantelau; X Y Ma; S Herrnberger; C Dohmen; P Trappe; T Baba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes     Volume:  39     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-08-30     Completed Date:  1990-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  938-41     Citation Subset:  AIM; IM    
Department of Metabolic Diseases and Nutrition, World Health Organization Collaborating Center for Diabetes, Düsseldorf, Federal Republic of Germany.
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MeSH Terms
Arteries / pathology*
Calcinosis / metabolism,  pathology,  physiopathology*
Diabetic Neuropathies / metabolism,  pathology,  physiopathology*
Exercise / physiology*
Foot / blood supply*,  physiopathology
Foot Diseases / metabolism,  pathology,  physiopathology
Ischemia / metabolism,  pathology,  physiopathology*
Oxygen / metabolism
Vascular Diseases / metabolism,  pathology,  physiopathology
Reg. No./Substance:

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