| Effect and mechanism of intermittent myocardial ischemia induced by exercise on coronary collateral formation. | |
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MedLine Citation:
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PMID: 18688201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To hypothesize that appropriate intermittent myocardial ischemia induced by exercise could safely promote coronary collateral formation in the ischemic area through the increased expression of vascular endothelial growth factor (VEGF) and its receptor fetal liver kinase-1 (Flk-1). DESIGN: A balloon constrictor was surgically implanted in the first obtuse marginal coronary artery (OM1) of Guangxi BA-MA miniature pigs. The subjects were divided into three groups: sham-operated (SO), pure ischemia (PI), and exercise training (ET). Subjects in the ET group performed individualized treadmill programs with two episodes of exercise-induced ischemia for 8 wks; two preexercise episodes of pure ischemia induced by brief OM1 occlusion were also conducted. Only pure ischemia was induced in the PI group, and the SO group remained sedentary for the experimental period. VEGF and Flk-1 expression levels were measured by Western blot and real-time reverse transcription polymerase chain reaction analyses; capillary density by immunohistochemistry; relative myocardial blood flow by microspheres; and cardiac troponin I by enzyme-linked immunosorbent assay. RESULTS: The relative myocardial blood flow, VEGF, Flk-1, and capillary density in the ET group were statistically higher than those in the PI and SO groups. All parameters in the PI group were statistically higher than those in the SO group. There was no myocardial damage in the ET or PI groups by cardiac troponin I. CONCLUSIONS: Intermittent myocardial ischemia induced by exercise with optimal stimulation safely promotes coronary collateral formation through increased VEGF and Flk-1 expression in a porcine model. |
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Authors:
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Xiao Lu; Tao Wu; Peng Huang; Song Lin; Feng Qiu; Xiangbo Meng; Jing Gao; Jianan Li |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Volume: 87 ISSN: 1537-7385 ISO Abbreviation: Am J Phys Med Rehabil Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-10-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8803677 Medline TA: Am J Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 803-14 Citation Subset: AIM; IM |
Affiliation:
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First Affiliated Hospital of Nanjing Medical University, Nanjing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collateral Circulation / physiology Coronary Angiography Coronary Stenosis / physiopathology Electrocardiography Motor Activity* Myocardial Ischemia / etiology*, metabolism, physiopathology Swine Swine, Miniature Troponin I / blood Vascular Endothelial Growth Factor A / metabolism* Vascular Endothelial Growth Factor Receptor-2 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Troponin I; 0/Vascular Endothelial Growth Factor A; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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