| Effect and mechanism of esmolol given during cardiopulmonary resuscitation in a porcine ventricular fibrillation model. | |
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MedLine Citation:
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PMID: 19581034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of the study was to investigate the effect on calcium cycling protein and electrical restitution of beta(1)-adrenergic receptor antagonist esmolol administered during cardiopulmonary resuscitation in the porcine ventricular fibrillation model. METHODS: Ventricular fibrillation untreated for four minutes was induced by dynamic steady state pacing protocol in 40 healthy male pigs, in which local unipolar electrograms were recorded using one 10-electrode catheter that was sutured to the left ventricular epicardium. During CPR, animals were randomized into two groups to receive saline as placebo or esmolol after two standard doses of epinephrine. At post-resuscitation 2-h, six pigs were randomly selected from each group and the second VF induction was performed. Local activation-recovery intervals (ARI) restitutions and the VF inducibility between control group and esmolol group were compared. Western blotting was performed to determine expression of Ca(2+)/calmodulin-dependent protein kinase IIdelta(CaMKIIdelta) and cardiac ryanodine receptor (RyR2) protein, and their phosphorylation status. RESULTS: Injection of esmolol combined with epinephrine during CPR significantly decreased recurrent rate of ventricular fibrillation during 2-h post-resuscitation, meanwhile it has no adverse affect on the restore of spontaneous circulation. Esmolol significantly flattened ARI restitution slope, lessened regional difference of ARI restitution, decreased the VF inducibility, and alleviated CaMKIIdelta hyper-activation and RyR2 hyper-phosphorylation. CONCLUSIONS: Esmolol given during CPR has significant effects on modulating electrical restitution property and intracellular calcium handling, which contributes the most important reasons why beta(1)-blockade significantly reduced the onset and maintenance of VF. |
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Authors:
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Lü Jingjun; Zhang Yan; Weijie; Zhao Dongdong; Lin Guosheng; Bao Mingwei |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-05 |
Journal Detail:
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Title: Resuscitation Volume: 80 ISSN: 1873-1570 ISO Abbreviation: Resuscitation Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-17 Completed Date: 2009-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 1052-9 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, RenMin Hospital of Wuhan University, Wuhan 430060, China. lvjingjun@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
therapeutic use* Animals Blotting, Western Calcium-Calmodulin-Dependent Protein Kinase Type 2 / biosynthesis, drug effects Cardiopulmonary Resuscitation / methods* Disease Models, Animal Electrocardiography / drug effects* Heart Ventricles / drug effects, metabolism, physiopathology Male Phosphorylation / drug effects Phosphotransferases Propanolamines / administration & dosage, therapeutic use* Ryanodine Receptor Calcium Release Channel / biosynthesis, drug effects Treatment Outcome Ventricular Fibrillation / metabolism, physiopathology, therapy* Ventricular Function / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 0/Ryanodine Receptor Calcium Release Channel; 84057-94-3/esmolol; EC 2.7.-/Phosphotransferases; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinase Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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