Document Detail

Effect of mechanical aortic valve orientation on coronary artery flow: comparison of tilting disc versus bileaflet prostheses in pigs.
MedLine Citation:
PMID:  12407375     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Orientation for optimal systolic performance of tilting disc and bileaflet aortic valves was defined in previous studies. The present study investigates the influence of valve orientation on coronary artery flow in an animal model. METHODS: A rotation device holding either a Medtronic Hall tilting disc (n = 4; Medtronic, Inc, Minneapolis, Minn), a St Jude Medical bileaflet (n = 4; St Jude Medical, Inc, St Paul, Minn), or a Medtronic Advantage bileaflet (n = 3) aortic valve was implanted. The device allowed rotation of the valve without reopening the aorta. Flow through the left anterior descending coronary artery was measured preoperatively and at normal versus high cardiac output after weaning from extracorporeal circulation. Measurements were performed at the best and worst hemodynamic position, as defined previously. RESULTS: Coronary flow rates were similar in all animals preoperatively (26 +/- 4.1 mL/min). After aortic valve replacement, left anterior descending flow increased significantly to 58.2 +/- 10.6 mL/min. Highest flow rates at normal cardiac output were found in the optimum orientation, especially for the Medtronic valves (Medtronic Hall, 64 +/- 8.7 mL/min; Medtronic Advantage, 64.6 +/- 11.6 mL/min; St Jude Medical, 48.3 +/- 10.3 mL/min), whereas the worst position demonstrated significantly lower left anterior descending flow, with no differences among valves (Medtronic Hall, 37.5 +/- 1.3 mL/min; St Jude Medical, 35.7 +/- 10.7 mL/min; Medtronic Advantage, 39.8 +/- 10 mL/min). Left anterior descending artery flow increased significantly with higher cardiac output. CONCLUSIONS: Coronary blood flow was significantly influenced by mechanical aortic valve implantation and the orientation of prostheses. For both valve designs, the previously defined optimum orientation with respect to pressure gradients and turbulence demonstrated the highest left anterior descending flow rates. Even in its optimum orientation, the St Jude Medical valve showed significantly lower coronary flow than the other valves.
Peter Kleine; Mirella Scherer; Ulf Abdel-Rahman; Armin A Klesius; Hans Ackermann; Anton Moritz
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  124     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  925-32     Citation Subset:  AIM; IM    
Department of Thoracic & Cardiovascular Surgery and the Department of Biomedical Statistics, Johann-Wolfgang-Goethe University, Frankfurt/Main, Germany.
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MeSH Terms
Aortic Valve / physiology*,  surgery*
Arteries / chemistry*,  physiology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology
Cardiac Output / physiology
Coronary Vessels / chemistry*,  physiology*
Diastole / physiology
Heart Rate / physiology
Heart Valve Prosthesis Implantation*
Models, Animal
Models, Cardiovascular
Prosthesis Design
Reference Values
Systole / physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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