Document Detail

Effect measures for behavioral factors adversely affecting fetal growth.
MedLine Citation:
PMID:  8672184     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to estimate the proportion of ultrasonically diagnosed fetal growth retardation that may be attributable to potentially remediable factors (for example, cigarette smoking, alcohol use, and drug addition). We computed multivariate odds ratios for fetal growth retardation associated with cigarette smoking and alcohol and illicit drug consumption in 350 singleton pregnancies complicated by fetal growth retardation and 700 controls. The odds ratio of fetal growth retardation among women who smoked throughout pregnancy was 2.61 (95% confidence interval, 1.38 to 4.93) compared to women who claimed to have stopped smoking by the 18th week of gestation. The summary attributable risk of fetal growth retardation associated with behavioral variables measured during the first trimester and thereafter ranged from 18 to 21%. By implication, the maximum proportion of fetal growth retardation that could theoretically be prevented by eliminating these risk factors accounts for about 1% of all births. However, allowance for the limited modifiability of preventable factors and the consistent overlap between them would probably reduce such estimate to less than 1%. We conclude that only interventions to reduce the prevalence of strong risk factors (for example, preeclampsia, sociodemographic variables) may have a substantial effect on the incidence of impaired fetal growth and subsequent infant morbidity.
A Spinillo; E Capuzzo; G Piazzi; F Baltaro; A Iasci; S Nicola
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  13     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-08-15     Completed Date:  1996-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Clinica Ostetrico-Ginecologica, IRCCS Policlinico San Matteo, Pavia, Italy.
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MeSH Terms
Alcohol Drinking / adverse effects*,  epidemiology
Case-Control Studies
Fetal Growth Retardation / epidemiology,  etiology*,  ultrasonography
Odds Ratio
Pregnancy Complications* / epidemiology
Risk Factors
Smoking / adverse effects*,  epidemiology
Substance-Related Disorders / complications*,  epidemiology
Ultrasonography, Prenatal
Weight Gain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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