Document Detail

Effect of measles-virus infection and interferon treatment on invasiveness of Shigella flexneri in HEp2-cell cultures.
MedLine Citation:
PMID:  3098977     Owner:  NLM     Status:  MEDLINE    
The influence of measles-virus infection on the invasiveness of Shigella flexneri in HEp2-cell cultures was studied. Bacterial invasiveness was significantly enhanced in cell cultures incubated with virus before bacterial inoculation. This effect was a function of time after introduction of virus to the cell cultures and of the concentration of virus. The increase in bacterial invasiveness was observed before production of infectious virus particles and before a cytopathic effect was evident. A similar enhancement of invasiveness was demonstrated when cell cultures were pretreated with UV-inactivated measles virus. Pretreatment of cells with interferon did not influence invasiveness, although it reduced the effect of measles-virus infection.
G Bukholm; K Modalsli; M Degré
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  22     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-41     Citation Subset:  IM    
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MeSH Terms
Bacterial Adhesion
Cell Line
Interferon Type I / pharmacology*
Interferon-gamma / pharmacology*
Measles virus / physiology*,  radiation effects
Shigella flexneri / pathogenicity*
Ultraviolet Rays
Reg. No./Substance:
0/Interferon Type I; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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