Document Detail


Effect of meal size and composition on the bioavailability of ketoprofen (Oruvail).
MedLine Citation:
PMID:  3604255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven young male volunteers received a single oral dose of Oruvail (ketoprofen 200 mg capsule) on two occasions, immediately after either a light/lean or a heavy/fatty meal at breakfast time. Administration of ketoprofen immediately following the heavy meal slightly, but significantly, delayed the absorption of the drug, as evidenced by mean (+/- S.D.)Tmax values of 6.7 (+/- 1.0) and 9.0 (+/- 1.4) hours respectively. Changing the type of meal had no statistically significant effect on the maximum plasma level, apparent plasma elimination half-life (t 1/2 h), area under the plasma level versus time curve, total plasma clearance, and urinary recovery of total ketoprofen, indicating that the bioavailability (and the systemic level) of ketoprofen was not affected by meal composition.
Authors:
J G Nievel; C W Havard; P Mitchell; A Gudgeon; C M Kaye
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  17     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-31     Completed Date:  1987-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  487-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Biological Availability
Dietary Fats / administration & dosage,  pharmacology
Energy Intake
Food*
Half-Life
Humans
Intestinal Absorption
Ketoprofen / metabolism*
Kinetics
Male
Phenylpropionates / metabolism*
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Phenylpropionates; 22071-15-4/Ketoprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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