| Effect of maternal and postweaning folic Acid supplementation on mammary tumor risk in the offspring. | |
| | |
MedLine Citation:
|
PMID: 21135116 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Intrauterine and early life exposure to folic acid has significantly increased in North America owing to folic acid fortification, widespread supplemental use, and periconceptional supplementation. We investigated the effects of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring. Female rats were placed on a control or folic acid-supplemented diet prior to mating and during pregnancy and lactation. At weaning, female pups from each maternal diet group were randomized to the control or supplemented diet and mammary tumors were induced with 7,12 dimethylbenz[a]anthracene at puberty. At necropsy, mammary tumor parameters, genomic DNA methylation, and DNA methyltransferase activity were determined in the offspring. Both maternal and postweaning folic acid supplementation significantly increased the risk of mammary adenocarcinomas in the offspring (OR = 2.1, 95% CI 1.2-3.8, P = 0.008 and OR = 1.9, 95% CI 1.1-3.3, P = 0.03, respectively). Maternal folic acid supplementation also significantly accelerated the rate of mammary adenocarcinoma appearance (P = 0.002) and increased the multiplicity of mammary adenocarcinomas (P = 0.008) in the offspring. Maternal, but not postweaning, folic acid supplementation significantly reduced global DNA methylation (P = 0.03), whereas postweaning, but not maternal, folic acid supplementation significantly decreased DNA methyltransferase activity (P = 0.05) in nonneoplastic mammary glands of the offspring. Our findings suggest that a high intrauterine and postweaning dietary exposure to folic acid may increase the risk of mammary tumors in the offspring. Further, they suggest that this tumor-promoting effect may be mediated in part by altered DNA methylation and DNMT activity. Cancer Res; 71(3); 988-97. ©2010 AACR. |
| | |
Authors:
|
Anna Ly; Hanna Lee; Jianmin Chen; Karen K Y Sie; Richard Renlund; Alan Medline; Kyoung-Jin Sohn; Ruth Croxford; Lilian U Thompson; Young-In Kim |
Related Documents
:
|
21246506 - Enhancing the enzymatic hydrolysis of lignocellulosic biomass by increasing the carboxy... 21389016 - Rapid behavioural diagnosis of domoic acid toxicosis in california sea lions. 21478316 - Increase of eicosapentaenoic acid in thraustochytrids through thraustochytrid ubiquitin... 11731336 - Enzymatic and non-enzymatic lipid peroxidation in leaf development. 3451956 - Effect of allopurinol on the intestinal absorption of 6-mercaptopurine in rats. 4031016 - Fatty acid compositions of serum lipids, erythrocytes, and platelets in insulin-depende... |
Publication Detail:
|
Type: Journal Article Date: 2010-12-06 |
Journal Detail:
|
Title: Cancer research Volume: 71 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
|
Languages: eng Pagination: 988-97 Citation Subset: IM |
Affiliation:
|
Authors' Affiliations: Departments of Nutritional Sciences, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto; Department of Pathology, Humber River Regional Hospital; Statistical Consultant, University of Toronto; and Division of Gastroenterology, St. Michael's Hospital, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hedgehog signaling drives cellular survival in human colon carcinoma cells.
Next Document: Mitotic exit control of the Saccharomyces cerevisiae Ndr/LATS kinase Cbk1 regulates daughter cell se...