Document Detail

Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania.
MedLine Citation:
PMID:  16452331     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the association between maternal multivitamin supplementation and the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania, as secondary endpoints in a randomized trial that investigated the effect of maternal multivitamin supplementation on HIV-1 vertical transmission and progression. METHODS: The Bayley Scales of Infant Development, 2nd Edition, were administered at 6, 12, and 18 months of age to a subset of children (N = 327). We assessed the effect of vitamin A and multivitamin (vitamins B, C, and E) supplementation using linear regression models and Cox proportional hazard models for the Mental Development Index, the Psychomotor Development Index, and raw scores separately. RESULTS: Multivitamin supplementation was associated significantly with a mean increase in Psychomotor Development Index score of 2.6 (95% confidence interval: 0.1-5.1). Multivitamins were also significantly protective against the risk for developmental delay on the motor scale (relative risk: 0.4; 95% confidence interval: 0.2-0.7) but not on the Mental Development Index. Vitamin A supplementation had no significant effect on these outcomes. CONCLUSIONS: Maternal multivitamin supplements provide a low-cost intervention to reduce the risk for developmental delays among infants who are born to HIV-positive mothers in developing countries.
Nuala McGrath; David Bellinger; James Robins; Gernard I Msamanga; Edward Tronick; Wafaie W Fawzi
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatrics     Volume:  117     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-02-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e216-25     Citation Subset:  AIM; IM    
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Child Development*
Developing Countries*
Dietary Supplements*
Double-Blind Method
HIV Infections / therapy*
Infant, Newborn
Neuropsychological Tests
Pregnancy Complications, Infectious / therapy*
Prenatal Care*
Psychomotor Performance
Vitamins / administration & dosage*
Grant Support
D43 TW00004/TW/FIC NIH HHS; R01 32257//PHS HHS; T32-AI-07358/AI/NIAID NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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