Document Detail


Effect of maternal micronutrients (folic acid, vitamin B(12)) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats.
MedLine Citation:
PMID:  22133376     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A disturbed fatty acid metabolism increases the risk of adult non-communicable diseases. This study examines the effect of maternal micronutrients on the fatty acid composition, desaturase activity, mRNA levels of fatty acid desaturases and transport proteins in the liver. Pregnant female rats were divided into 6 groups at 2 levels of folic acid both in the presence and absence of vitamin B(12). The vitamin B(12) deficient groups were supplemented with omega 3 fatty acid. An imbalance of maternal micronutrients reduces liver docosahexaenoic acid, increases Δ5 desaturase activity but decreases mRNA levels, decreases Δ6 desaturase activity but not mRNA levels as compared to control. mRNA level of Δ5 desaturase reverts back to the levels of the control group as a result of omega 3 fatty acid supplementation. Our data for the first time indicates that maternal micronutrients differentially alter the activity and expression of fatty acid desaturases in the liver.
Authors:
Nisha S Wadhwani; Rupali R Manglekar; Kamini D Dangat; Asmita V Kulkarni; Sadhana R Joshi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-29
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  -     ISSN:  1532-2823     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.
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