Document Detail

Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing.
MedLine Citation:
PMID:  12748510     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the effect of docosahexaenoic acid supplementation on plasma phospholipid docosahexaenoic acid content and indices of depression and information processing for women who breast-feed. STUDY DESIGN: Mothers who planned to breast-feed their infants were assigned randomly in a double-masked fashion to receive either docosahexaenoic acid (approximately 200 mg/d) or placebo for the first 4 months after the delivery. Major outcome variables included plasma phospholipid fatty acid patterns and scores on a self-rating questionnaire of current depression symptoms. A structured clinical interview of depression, scores on another self-rating questionnaire of depression symptoms, and a laboratory measure of information processing were obtained in subgroups of the total population. RESULTS: Plasma phospholipid contents of docosahexaenoic acid at baseline were 3.15 +/- 0.78 and 3.31 +/- 0.70 (mg/dL of total fatty acids) in the docosahexaenoic acid and placebo groups, respectively. After 4 months, the plasma phospholipid docosahexaenoic acid content of the docosahexaenoic acid group was 8% higher (3.40 +/- 0.97 mg/dL), whereas that of the placebo group was 31% lower (2.27 +/- 0.87 mg/dL). Despite the higher plasma phospholipid docosahexaenoic acid content of the supplemented group after 4 months, there was no difference between groups in either self-rating or diagnostic measures of depression; information processing scores of the two groups also did not differ. CONCLUSION: Docosahexaenoic acid supplementation ( approximately 200 mg/d) for 4 months after the delivery prevented the usual decline in plasma phospholipid docosahexaenoic acid content of women who breastfeed but did not influence self-ratings of depression, diagnostic measures of depression, or information processing.
Antolin M Llorente; Craig L Jensen; Robert G Voigt; J Kennard Fraley; Marcia C Berretta; William C Heird
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  188     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-15     Completed Date:  2003-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1348-53     Citation Subset:  AIM; IM    
Department of Pediatrics, United States Department of Agriculture, Agricultural Research Service Children's Nutrition Research Center, Houston, TX, USA.
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MeSH Terms
Breast Feeding
Depression, Postpartum / diagnosis,  psychology*
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*,  blood
Drug Administration Schedule
Fatty Acids / blood
Longitudinal Studies
Mental Processes
Phospholipids / blood
Postpartum Period
Self Concept
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 25167-62-8/Docosahexaenoic Acids
Comment In:
Am J Obstet Gynecol. 2004 Feb;190(2):582-3; author reply 583   [PMID:  15002412 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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