Document Detail

Effect of maternal diabetes on phosphorylation of insulin-like growth factor binding protein-1 in cord serum.
MedLine Citation:
PMID:  15787669     Owner:  NLM     Status:  MEDLINE    
AIMS: The insulin-like growth factor (IGF) system is considered important in the regulation of fetal growth. Binding of IGFs to specific binding proteins (IGFBPs) modifies their actions. In fetal blood, IGFBP-1 is the primary IGF binding protein whose phosphorylation generates proteins with different affinities for IGF-I. We studied cord serum IGFBP-1 phosphoisoform profiles in normal pregnancies and in diabetic pregnancies, which are frequently complicated by macrosomia. RESEARCH DESIGN AND METHODS: Cord serum IGFBP-1 phosphoisoform concentrations were measured at birth by two immunoenzymometric assays in 67 pregnancies complicated by Type 1 diabetes, in 28 pregnancies complicated by insulin-treated gestational diabetes, and in 62 normal pregnancies. RESULTS: Cord serum highly phosphorylated IGFBP-1 (hpIGFBP-1) concentrations were lower in pregnancies complicated by Type 1 diabetes (204 +/- 36 microg/l, P = 0.032) and in pregnancies complicated by gestational diabetes (170 +/- 28 microg/l, P = 0.031) than in controls (316 +/- 34 microg/l). Cord serum lesser phosphorylated IGFBP-1 (lpIGFBP-1) concentrations were similar in diabetic and normal pregnancies (P = 0.692 between groups by analysis of variance). Relative birth weight correlated negatively with cord serum hpIGFBP-1 and lpIGFBP-1 in diabetic pregnancies, and with cord serum lpIGFBP-1 in normal pregnancies. CONCLUSIONS: Maternal diabetes is associated with suppressed hpIGFBP-1 but unaltered lpIGFBP-1 concentrations in cord serum, suggesting that IGFBP-1 phosphoisoforms are differentially regulated in the fetus. Because hpIGFBP-1 has a higher affinity for IGF-I than does lpIGFBP-1, diabetes-related changes in fetal IGFBP-1 phosphorylation may increase IGF-I bioavailability and, consequently, stimulate fetal growth. This may partly explain the increased occurrence of macrosomia in diabetic pregnancies.
M Loukovaara; P Leinonen; K Teramo; E Nurminen; S Andersson; E-M Rutanen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  22     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-24     Completed Date:  2005-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  434-9     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Birth Weight
Diabetes Mellitus, Type 1 / blood*
Diabetes, Gestational / blood*
Fetal Blood / metabolism
Immunoenzyme Techniques
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Proteins / blood*
Pregnancy Proteins / blood*
Pregnancy in Diabetics / blood*
Protein Isoforms / blood
Reg. No./Substance:
0/IGFBP1 protein, human; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Proteins; 0/Pregnancy Proteins; 0/Protein Isoforms

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