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Effect of maternal betamethasone on fetal and uteroplacental blood flow velocity waveforms.
MedLine Citation:
PMID:  21077152     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To investigate effects of antenatal betamethasone on fetal and uteroplacental hemodynamics. MATERIAL AND METHODS: The study comprised 33 women with singleton high-risk pregnancies (23-33 completed weeks; 27 pregnancies < 30 weeks) not in labour, but at risk for preterm delivery on fetal or maternal indications. They were treated with two doses of 12 mg betamethasone intramuscularly 24 h apart to enhance fetal lung maturity. Flow velocity waveforms were recorded with Doppler ultrasound from umbilical artery, fetal middle cerebral artery, ductus venosus and both maternal uterine arteries once before and twice after the betamethasone administration. 21 women were delivered within 4 days, 9 women 5-7 days and 3 women up to 15 days after the first dose of betamethasone. RESULTS: Two days after betamethasone a decrease in pulsatility index was found in the umbilical artery (p = 0.0002) and ductus venosus (p = 0.003). Changes in the umbilical artery waveform from reverse to absent and from absent to positive diastolic flow were noted in 12 of 15 cases (p<0.01). After 4 days, in undelivered fetuses, umbilical artery and ductus venosus velocity waveforms either returned to the type of waveform before treatment or showed further deterioration. No significant effects of betamethasone were observed in the fetal middle cerebral artery and uteroplacental circulation. CONCLUSION: Maternal antenatal betamethasone caused a significant transient change in the velocity waveform and decrease of pulsatility index in the umbilical artery and ductus venosus, but did not influence the uteroplacental circulation. The findings indicate a direct effect of betamethasone on fetal circulation. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Ann Thuring; Peter Malcus; Karel Maršál
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-12
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Clinical Sciences Lund, Lund University, Sweden.
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