Document Detail

Effect of maternal age on uterine flow impedance.
MedLine Citation:
PMID:  15690442     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was conducted to determine possible maternal age-related changes in uterine artery impedance in normal late pregnancy. PATIENTS AND METHODS: In a cross-sectional design study, Doppler velocimetry of the uterine vessels was performed in 884 pregnant women with normal, late, singleton pregnancies. We hypothesized that maternal age is associated with changes in uterine blood flow Doppler parameters. We tested for univariate associations and for an adjusted relationship between these factors using a multivariate model to control for confounders. RESULTS: We found a statistically significant, nonlinear relationship between mean uterine artery impedance (pulsatility index) and maternal age, with an increase of the pulsatility index in women above the age of 35. This association continued to be significant even when adjusted for gestational age and parity as confounders. CONCLUSIONS: In normal pregnancy, an increase in uterine artery impedance was noted in women above the age of 35. This finding may be related to the physiologic process of aging and may partly explain why pregnancies in older women are associated with diverse complications more often than those in younger women.
Jouko Pirhonen; Tone Kristin Bergersen; Michael Abdlenoor; Marius Dubiel; Saemundur Gudmundsson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  33     ISSN:  0091-2751     ISO Abbreviation:  J Clin Ultrasound     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-03     Completed Date:  2005-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-7     Citation Subset:  IM    
Copyright Information:
2004 Wiley Periodicals, Inc.
Ullevaal University Hospital, Department of Obstetrics and Gynecology, University of Oslo, Kirkeveien 166, N-0407, Oslo, Norway.
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MeSH Terms
Aging / physiology
Cross-Sectional Studies
Electric Impedance
Maternal Age*
Middle Aged
Regional Blood Flow
Ultrasonography, Prenatal*
Uterus / blood supply*

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