Document Detail


Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels.
MedLine Citation:
PMID:  8964734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute physical exercise increases growth hormone (GH) secretion, and GH regulates the expression of insulin-like growth factor I (IGF-I) and IGF-binding protein (IGFBP) 3. IGFBP-1 is a local modulator of IGF activity with rapid dynamic regulation that is downregulated by insulin. The IGF system mediates the metabolic actions of GH, and possibly it regulates glucose metabolism. We hypothesize that strenuous exercise causes changes in the IGF system. We studied the effects of the marathon run on the circulating levels of IGF-I, IGFBP-1, IGFBP-3, and insulin in 23 participants. Immediately after the run, the most striking change was an 11.6-fold median increase in serum IGFBP-1 level (from 63.7 +/- 50.5 to 736 +/- 408 micrograms/l; P < 0.001). Because the insulin level remained unchanged, the elevation of serum IGFBP-1 level cannot be explained by changes in insulin. One day after the run, the IGFBP-1 level had returned to baseline. The physiological role of this increment could be the inhibition of hypoglycemic effects of IGF-I and/or regulation of glucose availability to the muscles. The changes in IGF-I and IGFBP-3 levels were less dramatic: the IGF-I and IGFBP-3 levels were lower 1 and 3 days after the run. This report provides an important basis for authentic effects of strenuous exercise on the IGF-system.
Authors:
H Koistinen; R Koistinen; L Selenius; Q Ylikorkala; M Seppälä
Related Documents :
15886244 - Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induce...
20725124 - Individual exercise sessions alter circulating hormones and cytokines in hiv-infected men.
21466104 - Use of ratings of perceived exertion to anticipate treadmill test termination in patien...
1314174 - Changes in the exercise-induced hormone response to branched chain amino acid administr...
22454894 - The assessment of β-adrenoceptor blocking drugs in hyperthyroidism.
6242354 - Exercise testing in lower-extremity arterial occlusive disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  80     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  760-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Carrier Proteins / blood*
Exercise / physiology*
Female
Humans
Insulin-Like Growth Factor I / metabolism*
Male
Middle Aged
Running / physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Carrier Proteins; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of a single bout of exercise on glucose effectiveness.
Next Document:  Adaptive responses to muscle lengthening and shortening in humans.