Document Detail

Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  19697997     Owner:  NLM     Status:  MEDLINE    
The effect of a mangosteen product containing multivitamins and essential minerals was tested on immune function and well-being in healthy adults. A randomized, double blinded, placebo-controlled study was conducted in 59 healthy human subjects (40-60 years old). Changes from baseline immune function were measured after a 30-day consumption of the mangosteen product and the placebo. The subjects' self-appraisal of their health status was also surveyed. A xanthone-rich mangosteen product intake increased mean values for peripheral T-helper cell frequency (P = .020) and reduced the serum C-reactive protein concentration (P = .014). Increases in peripheral CD4/CD8 double-positive (DP) T-cell frequency and serum complement C3, C4, and interleukin (IL)-1alpha concentrations were significantly higher in the experimental group than in the placebo group (DP, P = .038; C3, P = .017; C4, P = .031; IL-1alpha, P = .006). At the end of study, serum IL-1alpha and IL-1beta concentrations in the study group were significantly higher than that in the placebo group (IL-1alpha, P = .033; IL-1beta, P = .04). Furthermore, more participants in the experimental group reported greatly improved overall health status compared with participants receiving placebo (P = .001). The results indicated that the intake of an antioxidant-rich product significantly enhanced immune responses and improved the subject's self-appraisal on his or her overall health status.
Yu-Ping Tang; Peng-Gao Li; Miwako Kondo; Hong-Ping Ji; Yan Kou; Boxin Ou
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of medicinal food     Volume:  12     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-08     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-63     Citation Subset:  IM    
Department of Preventive Medicine, Yanjing Medical School, School of Public Health and Family Medicine, Capital Medical University, Beijing.
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MeSH Terms
C-Reactive Protein / metabolism
CD4-CD8 Ratio
Complement C3 / metabolism
Complement C4 / metabolism
Dietary Supplements*
Double-Blind Method
Garcinia mangostana* / chemistry
Health Status*
Immune System / drug effects*
Interleukin-1alpha / blood
Interleukin-1beta / blood
Middle Aged
Plant Preparations / pharmacology*
T-Lymphocytes, Helper-Inducer / metabolism
Xanthones / pharmacology
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/Interleukin-1alpha; 0/Interleukin-1beta; 0/Plant Preparations; 0/Xanthones; 90-47-1/xanthone; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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