| Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 19697997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of a mangosteen product containing multivitamins and essential minerals was tested on immune function and well-being in healthy adults. A randomized, double blinded, placebo-controlled study was conducted in 59 healthy human subjects (40-60 years old). Changes from baseline immune function were measured after a 30-day consumption of the mangosteen product and the placebo. The subjects' self-appraisal of their health status was also surveyed. A xanthone-rich mangosteen product intake increased mean values for peripheral T-helper cell frequency (P = .020) and reduced the serum C-reactive protein concentration (P = .014). Increases in peripheral CD4/CD8 double-positive (DP) T-cell frequency and serum complement C3, C4, and interleukin (IL)-1alpha concentrations were significantly higher in the experimental group than in the placebo group (DP, P = .038; C3, P = .017; C4, P = .031; IL-1alpha, P = .006). At the end of study, serum IL-1alpha and IL-1beta concentrations in the study group were significantly higher than that in the placebo group (IL-1alpha, P = .033; IL-1beta, P = .04). Furthermore, more participants in the experimental group reported greatly improved overall health status compared with participants receiving placebo (P = .001). The results indicated that the intake of an antioxidant-rich product significantly enhanced immune responses and improved the subject's self-appraisal on his or her overall health status. |
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Authors:
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Yu-Ping Tang; Peng-Gao Li; Miwako Kondo; Hong-Ping Ji; Yan Kou; Boxin Ou |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of medicinal food Volume: 12 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-08 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 755-63 Citation Subset: IM |
Affiliation:
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Department of Preventive Medicine, Yanjing Medical School, School of Public Health and Family Medicine, Capital Medical University, Beijing. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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C-Reactive Protein
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metabolism CD4-CD8 Ratio Complement C3 / metabolism Complement C4 / metabolism Dietary Supplements* Double-Blind Method Female Garcinia mangostana* / chemistry Health Status* Humans Immune System / drug effects* Interleukin-1alpha / blood Interleukin-1beta / blood Male Middle Aged Plant Preparations / pharmacology* T-Lymphocytes, Helper-Inducer / metabolism Xanthones / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C4; 0/Interleukin-1alpha; 0/Interleukin-1beta; 0/Plant Preparations; 0/Xanthones; 90-47-1/xanthone; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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