Document Detail

Effect of mandibular position on upper airway collapsibility and resistance.
MedLine Citation:
PMID:  15914594     Owner:  NLM     Status:  MEDLINE    
It has been proposed that advancement of the mandible is a useful method for decreasing upper airway collapsibility. We carried out this study to test the hypothesis that mandibular advancement induces changes in upper airway patency during midazolam sedation. To explore its effect, we examined upper airway pressure-flow relationships in each of 4 conditions of mouth position in normal, healthy subjects (n = 9). In the neutral position, Pcrit (i.e., critical closing pressure, an index of upper airway collapsibility) was -4.2 cm H(2)O, and upstream resistance (Rua) was 21.2 cm H(2)O/L/sec. In the centric occlusal position, Pcrit was -7.1 cm H(2)O, and Rua was 16.6 cm H(2)O/L/sec. In the incisor position, Pcrit was significantly reduced to -10.7 cm H(2)O, and Rua was significantly reduced to 14.0 cm H(2)O/L/sec. Mandibular advancement significantly decreased Pcrit to -13.3 cm H(2)O, but did not significantly influence Rua (22.1 cm H(2)O/L/sec). We conclude that the mandibular incisors' position improved airway patency and decreased resistance during midazolam sedation.
T Inazawa; T Ayuse; S Kurata; I Okayasu; E Sakamoto; K Oi; H Schneider; A R Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of dental research     Volume:  84     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  554-8     Citation Subset:  D; IM    
Nagasaki University Graduate School of Biomedical Sciences, Course of Medical and Dental Sciences, Department of Translational Medical Sciences, Division of Clinical Physiology, 1-7-1 Sakamoto, Nagasaki-shi, 852-8588, Japan.
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MeSH Terms
Airway Obstruction / physiopathology*
Airway Resistance / drug effects,  physiology*
Dental Occlusion, Centric
Hypnotics and Sedatives / administration & dosage,  pharmacology
Incisor / anatomy & histology
Inhalation / drug effects,  physiology
Inspiratory Capacity / drug effects,  physiology
Mandible / anatomy & histology*
Mandibular Advancement / instrumentation
Midazolam / administration & dosage,  pharmacology
Pulmonary Ventilation / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Hypnotics and Sedatives; 59467-70-8/Midazolam

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