Document Detail

Effect of maltodextrin and superdisintegrant in directly compressible powder mixtures prepared via co-spray drying.
MedLine Citation:
PMID:  17576058     Owner:  NLM     Status:  MEDLINE    
The effect of maltodextrins and superdisintegrants on the tablet properties was evaluated in directly compressible powders coprocessed via spray drying. Powder mixtures containing acetaminophen, mannitol, erythritol and different maltodextrin types were prepared via co-spray drying and physically mixed with crospovidone (6% w/w, Kollidon CL) in order to evaluate the influence of maltodextrin grade (amylose/amylopectin ratio) on powder hygroscopicity, flowability, density and compactability. In addition, different superdisintegrant types and grades (6% w/w) were co-spray dried to evaluate their effect on tablet disintegration time. Tablet disintegration was affected by the amylose/amylopectin ratio of the maltodextrins. Tablets containing Glucidex 2 (1-5% amylose) had a longer disintegration time compared to Glucidex 9 (20% amylose) (11.8min versus 5.7min) and Unipure DC (50-70% amylose) (1min). The disintegration time of tablets containing a coprocessed superdisintegrant was long due to loss of superdisintegrant during processing (preferential depositing on the spray dryer wall) and was in the following order: Kollidon CL<Polyplasdone XL<Explotab<Kollidon CL-M<Polyplasdone XL-10=Ac-Di-Sol. A combination of acetaminophen, mannitol, erythritol, Glucidex 9 and Kollidon CL was selected for further formulation and process optimisation of co-spray dried powders intended for direct compression.
Y Gonnissen; J P Remon; C Vervaet
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Publication Detail:
Type:  Journal Article     Date:  2007-05-13
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  68     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
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MeSH Terms
Chemistry, Pharmaceutical
Polysaccharides / chemistry*
Reg. No./Substance:
0/Polysaccharides; 0/Powders; 0/Tablets; 9050-36-6/maltodextrin

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