Document Detail

Effect of magnesium supplementation on blood pressure: a meta-analysis.
MedLine Citation:
PMID:  22318649     Owner:  NLM     Status:  MEDLINE    
To date, there has been inconclusive evidence regarding the effect of magnesium supplements on blood pressure (BP). This meta-analysis was conducted to assess the effect of magnesium supplementation on BP and to establish the characteristics of trials showing the largest effect size. Primary outcome measures were systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the end of the follow-up period. One hundred and forty-one papers were identified, of which 22 trials with 23 sets of data (n=1173), with 3 to 24 weeks of follow-up met the inclusion criteria, with a supplemented elemental magnesium range of 120-973 mg (mean dose 410 mg). 95% confidence intervals (CI) were calculated using DerSimonian and Laird's random-effects model, with effect size calculated using Hedges G. Combining all data, an overall effect of 0.36 and 0.32 for DBP and SBP, respectively, was observed (95% CI 0.27-0.44 for DBP and 0.23-0.41 for SBP), with a greater effect being seen for the intervention in crossover trials (DBP 0.47, SBP 0.51). Effect size increased in line with increased dosage. Although not all individual trials showed significance in BP reduction, combining all trials did show a decrease in SBP of 3-4 mm Hg and DBP of 2-3 mm Hg, which further increased with crossover designed trials and intake >370 mg/day. To conclude, magnesium supplementation appears to achieve a small but clinically significant reduction in BP, an effect worthy of future prospective large randomised trials using solid methodology.
L Kass; J Weekes; L Carpenter
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2012-02-08
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  66     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-04     Completed Date:  2012-07-30     Revised Date:  2012-10-30    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  411-8     Citation Subset:  IM    
School of Life Sciences, University of Hertfordshire, Hatfield, UK.
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MeSH Terms
Administration, Oral
Blood Pressure / drug effects*
Blood Pressure Determination
Confidence Intervals
Dietary Supplements*
Hypertension / drug therapy
Magnesium / administration & dosage*
Reg. No./Substance:
Comment In:
Eur J Clin Nutr. 2012 Sep;66(9):1075; author reply 1075   [PMID:  22739250 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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