| Effect of magnesium sulfate administration on subendocardial and subepicardial perfusion. | |
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MedLine Citation:
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PMID: 9494060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine the effect of systemic MgSO4 infusion on subendocardial and subepicardial perfusion. Seventeen spontaneously breathing piglets were examined. Myocardial perfusion was measured using radiolabeled microspheres at baseline, 30 and 60 min after either MgSO4 (80 mg/kg) or saline infusion. Blood pressure, heart rate, and cardiac output were also measured at these time intervals. Comparison of the magnesium-induced changes in systemic blood pressure and on subendocardial and subepicardial perfusion at 30 and 60 min with values obtained with saline solution at 30 and 60 min, yielded no statistically significant difference (Tables 1-3). The ratio of subendocardial/subepicardial blood flow and subendocardial and subepicardial coronary vascular resistance at 30 and 60 min revealed no statistically significant differences between the magnesium and the control group (Table 3). There were no statistically significant difference in cardiac output and heart rate during any of the measured periods (Table 2). Our results suggest that the administration of MgSO4 does not alter the ratio of subendocardial/subepicardial blood flow and the ratio of subendocardial/subepicardial coronary vascular resistance. |
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Authors:
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P Fantidis; T A Stiris; D Blanco; R M Jarabo; M J Del Cerro; M A Ruiz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological trace element research Volume: 60 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-06-23 Completed Date: 1998-06-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-34 Citation Subset: IM |
Affiliation:
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The Research Unit-Experimental Surgery, Hospital La Paz, Facultad de Medicina, Universidad Autonoma, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Blood Gas Analysis Blood Pressure / drug effects Cardiac Output / drug effects Coronary Circulation / drug effects* Heart / drug effects*, physiology, radionuclide imaging Heart Rate / drug effects Magnesium Sulfate / pharmacology* Microspheres Saline Solution, Hypertonic Swine Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Saline Solution, Hypertonic; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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